Results 101 to 110 of about 80,668 (194)

An Open-Label, Multicentre, Observational, Post-Marketing Study to Monitor the Safety and Effectiveness of Umeclidinium/Vilanterol in Korean Patients. [PDF]

Tuberc Respir Dis (Seoul), 2023
Cho EY, Cho JE, Lee EB, Yoo SS, Chang JH.   +4 more
europepmc   +1 more source

Reconstruction of Ultrafine MnS‐Induced Vacancy‐Rich Co9S6.29 Precatalysts in Mesoporous S‐Doped N‐Rich Hollow Carbon Nanotubes Enables Dynamic O‐Vacancy Cycling for High‐Performance Zn‐Air Batteries

Advanced Science, EarlyView.
We develop vacancy‐rich Co9S6.29 precatalysts formed via ultrafine MnS‐induced lattice distortion in mesoporous S‐doped N‐rich hollow carbon nanotubes (CM@SNHCTs). This CM@SNHCT precatalyst is reconstructed into catalytically‐active cathode phases that enable efficient oxygen reduction/evolution reactions (ORR/OER) through dynamic O‐vacancy formation ...
Debarani Devi Khumujam, Saleem Sidra, Ram Babu Ghising, Dong Won Kim, Jong Hui Choi, Gwanho Lee, Benzhi Wang, Hyung Mo Jeong, Sang‐Il Choi, Do Hwan Kim, Jeung Ku Kang   +10 more
wiley   +1 more source

Hyperpolarization of [1‐13C]Ketoisocaproate‐d2 by Reversible Exchange with Parahydrogen Enables Profiling of Branched‐Chain‐Amino‐Acid Metabolism in Cellulo and in Vivo

Advanced Science, EarlyView.
We report the fast generation of biocompatible solutions of highly 13C‐hyperpolarized (≈11%) partially‐deuterated ketoisocaproate within <6 min using spin‐lock‐induced crossing and reversible exchange with parahydrogen (SLIC‐SABRE). This enables rapid detection of branched‐chain‐amino‐acid transferase 1 (BCAT1) protein expression and investigation of ...
Stefan Petersen, Philipp R. Groß, Paul M. Schmidt, Henri de Maissin, Asitan Rittinger, Robert Willing, Adriana Sacristán‐Martín, Lisa Heß, Jule Koch, Sebastian Lucas, Maxim Zaitsev, Dominik von Elverfeldt, Martin Grashei, Franz Schilling, Jan‐Bernd Hövener, André F. Martins, Max von Delius, Thomas Reinheckel, Andreas B. Schmidt   +18 more
wiley   +1 more source

Safety of heterologous ChAdOx1-S/BNT162b2 primary schedule versus homologous BNT162b2 vaccination: Insights from an Italian post-marketing study, 2021. [PDF]

Hum Vaccin Immunother, 2023
Fortunato F, Prato R, Iannelli G, Ascatigno L, Loconsole D, Lopalco PL, Martinelli D.   +6 more
europepmc   +1 more source

Phase IV of Drug Development

Perspectives in Clinical Research, 2010
Not all Phase IV studies are post-marketing surveillance (PMS) studies but every PMS study is a phase IV study. Phase IV is also an important phase of drug development.
Viraj Suvarna
doaj  

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Safety and Effectiveness of Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice: An Observational Post-Marketing Study in Japan. [PDF]

Drugs Real World Outcomes, 2023
Furuse J, Izumi N, Motomura K, Inaba Y, Katamura Y, Kondo Y, Yabushita K, Motoyoshi K, Kudo M.   +8 more
europepmc   +1 more source

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Safety of 4-valent human papillomavirus vaccine in males: a large observational post-marketing study. [PDF]

Hum Vaccin Immunother, 2022
Amend KL, Turnbull B, Zhou L, Marks MA, Velicer C, Saddier P, Seeger JD.   +6 more
europepmc   +1 more source

Post-marketing surveillance framework of cell and gene therapy products in the European Union, the United States, Japan, South Korea and China: a comparative study

BMC Medicine
Background Cell and gene therapy products (CGTPs) often receive accelerated approvals, lacking comprehensive long-term safety and efficacy data, which can raise significant safety concerns. This research aims to study the post-marketing surveillance (PMS)
Yuxin Cai, Lijuan Sui, Jingjing Wang, Weilin Qian, Yeheng Peng, Luyao Gong, Weijia Wu, Yuan Gao   +7 more
doaj   +1 more source