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In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang +19 more
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Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar +10 more
wiley +1 more source
CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma +12 more
wiley +1 more source
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DeckerMed Anesthesiology, 2021
This general overview of the postanesthesia care unit (PACU) summarizes the most current standards and guidelines for patient care and monitoring. It also details the causes and treatment of the most common complications observed in PACU, such as postoperative nausea and vomiting, hemodynamic compromise, and respiratory insufficiency.
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This general overview of the postanesthesia care unit (PACU) summarizes the most current standards and guidelines for patient care and monitoring. It also details the causes and treatment of the most common complications observed in PACU, such as postoperative nausea and vomiting, hemodynamic compromise, and respiratory insufficiency.
openaire +1 more source
The Post Anesthesia Care Unit Experience
Journal of Nursing Care Quality, 2003The Post Anesthesia Care Unit (PACU) visitation program of Memorial Sloan-Kettering Cancer Center needed revision. The process was disorganized, visits were unescorted, and nurses and physicians were resistant. A committee was formed with the goal of developing a new unit philosophy and improving the overall process.
Lenore, Smykowski, Wanda, Rodriguez
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CARDIOVASCULAR EMERGENCIES IN THE POST ANESTHESIA CARE UNIT
Nursing Clinics of North America, 1993Optimizing the cardiac function of the postanesthesia patient is dependent on identifying the possible causes of dysfunction. The causes of alterations in cardiac function are varied and complex. The PACU nurse must possess a knowledge of cardiac physiology, an intricate understanding of the cardiovascular effects of various anesthetic agents, and ...
A S, Bines, S L, Landron
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Post Anesthesia Care Unit (PACU)
2010A healthy 4-year old has just undergone open reduction internal fixation of a midshaft femur fracture under general endotracheal anesthesia with an epidural in place which appeared to be functioning well during surgery. You are called to the bedside because he is in excruciating pain, clenching his teeth, crying, and he and his parents are wild.
Robert S. Holzman +3 more
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