Results 191 to 200 of about 6,651,279 (337)

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

RCT of post-conflict trauma interventions in the Central African Republic. [PDF]

Glob Ment Health (Camb)
Froming WJ, Van Zyl M, Froming KB, Bouche V, Patel SG.   +4 more
europepmc   +1 more source

A comparative study of posttraumatic stress disorder in two post-conflict communities in Benue state Nigeria. [PDF]

Dialogues Health, 2023
Edeh AN, Uwakwe R, Obindo TJ, Agbir MT, Akanni OO.   +4 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Transforming Health in Post-Conflict Somalia: Priorities from a Multi-Stakeholder Roundtable on the 2025-2029 National Plan. [PDF]

J Healthc Leadersh
Dirie NI, Ahmed MM, Abdullahi YB, Hassan J, Garba B, Mohamed AA, Hassan AH, Naleye Ali A, Abubakar AHA.   +8 more
europepmc   +1 more source

The impact of decentralisation on health systems in fragile and post-conflict countries: a narrative synthesis of six case studies in the Indo-Pacific. [PDF]

Confl Health, 2023
Brennan E, Abimbola S.
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

A Report from a Community-Centric Cancer Control Approach in the Post-Conflict Northern Province of Sri Lanka. [PDF]

Int J Environ Res Public Health
Dosumu AN, Thanenthiran AJ, Sritharan G, Mahendran T, Surenthirakumaran R, Sithamparanathan K, Asence S, Decker KM, Navaratnam S.   +8 more
europepmc   +1 more source

Correction: Mental health service accessibility, development and research priority setting in Cambodia - a post-conflict nation. [PDF]

BMC Health Serv Res, 2023
Maddock A, Ean N, Campbell A, Davidson G.   +3 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source