Results 41 to 50 of about 4,779 (160)

IL‐3 Modulates Microglia Polarization and Attenuates Neuroinflammation in Traumatic Brain Injury

Advanced Science, Volume 13, Issue 29, 22 May 2026.
IL‐3 recruits PRDX1 through IL‐3R to modulate the inflammatory response of microglia via the KEAP1‐NRF2‐HO‐1/NF‐κB pathway to attenuate neuroinflammation in traumatic brain injury. ABSTRACT Microglia play a crucial role in the progression of neuroinflammation following traumatic brain injury (TBI). Interleukin‐3 (IL‐3), a significant regulatory factor,
Nana Huang, Qingchen Zhang, Yanrui Chen, Dapeng Yu, Ronghan Liu, Jianning Kang, Xiang Fang, Ying Zhang, Hong Bian, Yanxin Zhao, Yongcheng Yin, Ce Zhang, Yanfei Jia, Qingfa Chen, Yuepeng Fang, Shang Li, Fang Li, Zhengxin Jin, Bin Ning   +18 more
wiley   +1 more source

Postpartum post-dural puncture headache: is your differential diagnosis complete?

, 2004
Contains fulltext : 57094.pdf (Publisher’s version ) (Closed access)We describe a patient with an intracerebral haemorrhage following an accidental dural puncture during an attempted epidural for pain relief in labour.
Bleeker, C.P., Booij, L.H.D.J., Hendriks, I.M.   +2 more
core   +1 more source

GAMBARAN KEJADIAN POST DURAL PUNCTURE HEADACHE (PDPH) DAN POST DURAL PUNCTURE BACKPAIN (PDPB) PADA PASIEN DENGAN ANESTESI SPINAL DI KOTA PADANG [PDF]

, 2020
Anestesi spinal merupakan salah satu bentuk anestesi regional yang banyak digunakan untuk tindakan bedah abdomen bagian bawah, daerah inguninal, dan ekstremitas bagian bawah.
Suci, Rahmawati Annabawi
core  

Post dural puncture headache

Journal of Institute of Medicine Nepal, 2010
Introduction: Post dural puncture headache occurs as the cerebrospinal fluid leaks out from the breach that the needle has made in the dura. The incidence of Post Dural Puncture Headache (PDPH) is a common complication after spinal anesthesia. The objective of our study is to find out incidence of PDPH in patients undergoing surgery under spinal ...
J Singh, S Ranjit, S Shrestha, T Limbu, S.B. Marhatha   +4 more
openaire   +1 more source

Intracranial Hypotension Following Spinal Manipulation: A Case Report and Scoping Review of the Literature

Brain and Behavior, Volume 16, Issue 5, May 2026.
Abstract Purpose Spinal manipulative therapies, including chiropractic and osteopathic maneuvers, are widely practiced for musculoskeletal complaints. However, rare but serious complications such as cerebrospinal fluid (CSF) leak with subsequent intracranial hypotension (IH) have been described.
Marina Romozzi, Matteo Palermo, Fabio Zeoli, Federico Tosto, Catello Vollono, Giuseppe Garignano, Francesco Signorelli   +6 more
wiley   +1 more source

Chronic Subdural Hematoma in a Patient With Long‐Standing Syphilis

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Chronic subdural hematoma can rarely occur in younger adults without trauma or coagulopathy. Comprehensive imaging to exclude vascular malformations, combined with burr hole evacuation and middle meningeal artery embolization, can achieve excellent outcomes.
Jose Marino, Vratko Himic, Felipe Monteiro, Joacir G. Cordeiro   +3 more
wiley   +1 more source

The Efficacy and Toxicity of CNS Prophylaxis in Diffuse Large B‐Cell Lymphoma (CLSG‐CNS‐01): A Randomized, Multicenter, Prospective Phase 3 Trial

Hematological Oncology, Volume 44, Issue 3, May 2026.
ABSTRACT The randomized, multicenter, prospective Phase 3 trial (NCT02777736) evaluated central nervous system (CNS) prophylaxis using either intravenous (i.v.) or intrathecal (i.t.) methotrexate (MTX) in diffuse large B‐cell lymphoma (DLBCL). Treatment consisted of six cycles of R‐CHOP + 2xR or DA‐EPOCH‐R + 2xR. Patients with intermediate or high‐risk
H. Mocikova, L. Gaherova, T. Jancarkova, A. Suri, A. Janikova, K. Steinerova, D. Belada, R. Pytlik, J. Duras, M. Trnkova, P. Blahovcova, T. Kozak, M. Trneny   +12 more
wiley   +1 more source

Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management

MedComm, Volume 7, Issue 5, May 2026.
The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang, Zijiao Tian, Zhaoquan Wang, Zerui Yang, Ziyao Wang, Zikang Wang, Ziqing Wang, Xingyuan He, Yu Yan, Yuanfeng Gong, Siyuan Xu, Xinyi Li, Guihua Tian   +12 more
wiley   +1 more source

First‐In‐Human Safety, Pharmacokinetics, and Pharmacodynamics of VENT‐02 Freebase, a CNS‐Penetrant NLRP3 Inhibitor

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT The NLRP3 inflammasome is a central mediator of innate immunity and a key driver of inflammatory and neurodegenerative diseases. VENT‐02 is orally bioavailable, central nervous system‐penetrant, selective small‐molecule inhibitor of NLRP3. This first‐in‐human, randomized, double‐blind, placebo‐controlled study assessed the safety, tolerability,
Lisanne C. A. Smidt, Matthijs Moerland, Manon A. A. Jansen, Philip H. C. Kremer, Alexandra A. J. Sille, Pamela K. Strugala, Erica S. Klaassen, Anick Auger, Silvana Jananji, Rania Faidi, Kelly A. Pike, Loraine Warner, Andre Matta, Xavier Valencia, Ofer Spiegelstein   +14 more
wiley   +1 more source

Reversible cerebral vasoconstriction syndrome: A narrative review

Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1162-1180, May 2026.
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
Ícaro Araújo de Sousa, Abner da Silva Machado, Arthur de Oliveira Veras, Thiago Oscar Goulart, Sarah Galassi Tatsuta, Trajano Aguiar Pires Gonçalves, Eva Rocha, Octávio Marques Pontes‐Neto   +7 more
wiley   +1 more source