Results 121 to 130 of about 5,937,067 (301)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Other title: Annual report of the Legislative Post Audit Committee and Legislative Division of Post Audit, fiscal year 1994

, 1995
Fiscal year ends June 30.; "January 10, 1995."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source

Direct 3D printing for post-emergency settlements

, 2020
We live in an era when the already precarious post-emergency housing conditions faced by millions of people have been dramatically transformed from something extraordinary into something ordinary. While waiting for reconstruction, everyday life is further complicated by the insufficient architectural and urban quality of temporary housing solutions ...
Paparella, Giulio, Percoco, Maura
openaire   +1 more source

The Nature of the Transformation in Transformational Emergence

, 2018
Discussion about the nature of the transformation in the case of transformational ...
Guay, Alexandre, Diachronic Emergence
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Weed Response to Different Tank-Mix Herbicide Combinations and its Impact on Winter Rice Performance in Zero Till Non-Puddled Condition

Fundamental and Applied Agriculture
Tank-mixture of two or more chemical groups of either pre- or post-emergence herbicide might play a vital role to manage weeds of a diversified community more effectively than their single or sequential application.
A K M Mominul Islam, Md. Abu Said, Mirfatun Rhaman, Israt Jahan, Sabina Yeasmin, Mahmudul Hasan, Mst. Motmainna, Md. Parvez Anwar   +7 more
doaj   +1 more source

Retraction: The impact of seed burial depths and post-emergence herbicides on seedling emergence and biomass production of wild oat (Avena fatua L.): Implications for management. [PDF]

PLoS One, 2022
PLOS ONE Editors.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Other title: Annual report of the Legislative Post Audit Committee and Legislative Division of Post Audit, fiscal year 2006

, 2006
Fiscal year ends June 30.; "November 20, 2006."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source

Post-emergence seedling damage due to vertebrate pests and its impact on soybean establishment. [PDF]

PeerJ, 2021
Lamichhane JR.
europepmc   +1 more source