Results 101 to 110 of about 5,918,554 (301)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Food Consumption Behavior in Bandung Post COVID-19 Pandemic Emergence

Journal of Management and Business Review
This research was done to discern changes in food consumption behavior in Indonesia two years after the emergence of the COVID-19 pandemic. Primary data for this research was gathered through questionnaires distributed from 26 June 2022 until 26 July ...
Yosephine Carolina Nugraha, Sabrina Wissen, Shafira Putri Kurniawan   +2 more
doaj   +1 more source

Statement: [Account of W.B. Post and Lincoln of August 21, 1863]

, 2012
Handwritten account of W.B. Post and Lincoln of August 21, 1863, signed W.B. Post, 4 pages.
Post, W.B.
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Citronella essential oil-based nanoemulsion as a post-emergence natural herbicide. [PDF]

Sci Rep, 2023
Somala N, Laosinwattana C, Chotsaeng N, Teerarak M.   +3 more
europepmc   +1 more source

Topographical deixis and the Tani languages of North East India [PDF]

, 2011
[Extract] In this paper, I will introduce the term topographical deixis to describe this sort of system as it is found in the Tani languages, which constitute a medium-sized branch of Tibeto-Burman languages spoken primarily in Arunachal Pradesh and ...
Post, Mark W., Post, Mark William
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Other title: Annual report of the Legislative Post Audit Committee and Legislative Division of Post Audit, fiscal year 2004

, 2004
Fiscal year ends June 30.; "November 18, 2004."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source

Other title: Annual report of the Legislative Post Audit Committee and Legislative Division of Post Audit, fiscal year 1993

, 1994
Fiscal year ends June 30.; "January 11, 1994."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source