Results 111 to 120 of about 5,916,091 (302)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Other title: Annual report of the Legislative Post Audit Committee and Legislative Division of Post Audit, fiscal year 2003

, 2003
Fiscal year ends June 30.; "November 18, 2003."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source

EFFECTIVENESS OF SOME POST-EMERGENCE HERBICIDES IN SOYBEAN [PDF]

Poljoprivreda, 2008
A three-year field experiment was conducted in soybean on lessive pseudogley soil at Čačinci locality (P.P. Orahovica d.d.) in North-eastern Croatia to evaluate the effectiveness of chemical weed control through single or multiple applications of post ...
Mira Knežević, Manda Antunović, Ljubica Ranogajec, Renata Baličević   +3 more
doaj  

Post-emergence herbicidal activity of nanoatrazine against Alternanthera tenella Colla plants compared to other weed species. [PDF]

Heliyon, 2022
Sousa BT, Pereira ADES, Fraceto LF, Oliveira HC, Dalazen G.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rapid On-Farm Testing of Resistance in Lolium rigidum to Key Pre- and Post-Emergence Herbicides. [PDF]

Plants (Basel), 2021
Perez MB, Beckie HJ, Cawthray GR, Goggin DE, Busi R.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Vapor and Liquid Phase Profiles of Essential Oils from Abies, Picea and Pinus Species and Their Phytotoxic Interactions with Weed Growth in Pre- and Post-Emergence Conditions. [PDF]

Plants (Basel), 2023
Garzoli S, Vaglia V, Iriti M, Vitalini S.   +3 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Other title: Annual report of the Legislative Post Audit Committee and Legislative Division of Post Audit, fiscal year 1994

, 1995
Fiscal year ends June 30.; "January 10, 1995."Constitutes the annual report of the ...
Kansas. Legislative Post Audit Committee.
core   +1 more source