Results 101 to 110 of about 918,872 (308)

Effect of severe environmental thermal stress on redox state in salmon

open access: yesRedox Biology, 2014
Fish are exposed to many kinds of environmental stressors and the chances of succumbing to infectious diseases may be increased a result. For example, an acute increase in temperature can induce numerous physiological changes in the body.
Toshiki Nakano   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Investigation of the Effect of Heat Treatment on the Microstructures and Mechanical Properties of Al-13Si-5Cu-2Ni Alloy

open access: yes, 2021
An experimental investigation was carried out to study the effects of solid solution treatment and aging treatment on the microstructures and mechanical properties of an Al-13Si-5Cu-2Ni alloy.
Feng Qiu   +4 more
core   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

The influence of post-weld heat treatment on microstructure of TC4 weld joints

open access: yes, 2015
The effect of one two-step high-temperature post-weld heat treatment on the microstructure of TC4 weld joints has been studied in our experiment, and as a result, the weld joints with attractive mechanical property have been obtained.
Hu, Y., Liu, J., Qiao HC(乔红超)
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Impact of Heat Treatment on Microstructure Evolution in Grey Cast Iron EN-GJL-300

open access: yes
This work investigated changes in the microstructure and local mechanical properties after the application of selected heat treatments to EN-GJL-300 grey cast iron.
Martin Bilka   +6 more
core   +1 more source

Mechanical properties and microstructure of SMAW welded and thermically treated HSLA-80 steel

open access: yesJournal of Materials Research and Technology, 2018
This paper aims to present a comparison on the use of different heat treatment conditions in association with welding of a HSLA-80 steel. This investigation was carried out by multipass welding using the coated electrode process in different heat ...
Leandro de Jesus Jorge   +6 more
doaj   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Laser heat treatment with latest system components

open access: yes, 2022
S.15-20Laser beam heat treatment has been established during the last years as a complementary technology for local hardening treatment tasks at tool manufacturing, automotive industry and many others. Recently developed new high power diode lasers and a
Bonß, Steffen   +6 more
core  

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