Results 61 to 70 of about 1,227,325 (301)

Study on Welding Process of Solid Phase Welding by Post Heat Treatment

open access: yesJournal of the Japan Welding Society, 1971
固相圧接における後熱温度,後熱時間,接合変形度の影響を検討した結果,次のような結論を得た.1.後熱処理による接合状況の進行過程は,後熱温度,後熱時間,接合変形度によって左右され,アレニウスの式を満足する.2.後熱初期の回復現象によって起る接合部に残留する弾性応力の緩和と,さらには後続する再結晶現象によって,接合境界の原子の移動,再配列が進み接合強さは向上する.3.接合境界状態の改善と母材の軟化現象との総合効果によって,継手の機械的性質は決定し,材質,接合変形度,温度によって定まるほぼ一定の後熱時間で最大値がえられた.4.後熱温度が高くなると,空洞の球状化および集合が起る結果,軟化によって低下した接合強さに再び増加が認められ,接合変形度の差の影響はなくなる傾向にある.
Tatsuya Hashimoto, Osamu Ohashi
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Evolution of the Heterogeneous Microstructure of a 12Cr1MoV Welded Joint after Post-Weld Heat Treatment and Its Effect on Mechanical Properties

open access: yesMetals, 2023
The non-uniformity of microstructures and mechanical properties across a whole welded joint is a crucial factor leading to its weakening performance and premature failure.
Bin Yang   +6 more
doaj   +1 more source

Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules. [PDF]

open access: yes, 2019
Covalent post-translational modification (PTM) of proteins with acyl groups of various carbon chain-lengths regulates diverse biological processes ranging from chromatin dynamics to subcellular localization.
Chua, Katrin F   +7 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Effect of Heat-Treatment Time on Bending Properties of Cobolt-Chromium Orthodontic Wires [PDF]

open access: yes, 2019
Different protocols appear in the literature with respect to heat-treating cobalt-chromium orthodontic wires. The objective was to determine the effect of variable heat-treatment time and method on the bending properties of CoCr wires.
Hammerbeck, Melanie
core   +1 more source

Response of A356 to warm rotary forming and subsequent T6 heat treatment

open access: yes, 2014
The through-process microstructural effects in A356 subjected to rotary forming at elevated temperatures have been investigated. Macro and micro-hardness testing have been used extensively to track changes in the material from the as-cast state to as ...
Maijer, D. M., Roy, M. J.
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Fatigue response of as built DMLS processed Maraging Steel and effects of machining and heat and surface treatments [PDF]

open access: yes, 2018
The main motivations for this study arise from the need for an assessment of the fatigue performance of DMLS produced Maraging Steel MS1, when it is used in the \u201cas fabricated\u201d state. The literature indicates a lack of knowledge from this point
Bogojevic, Nebojsa   +8 more
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy