Results 121 to 130 of about 81,308 (259)

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

A Universal Protein Ladder for Standardization of Diverse FRET Assays

Advanced Science, EarlyView.
Translating FRET measurements from in vitro to intracellular environments requires universal benchmarks. We present a modular protein ladder using TPR motifs to harmonize data across diverse platforms. This predictable calibration curve bridges single molecule FRET measurements, with cell based measurements including FLIM‐FRET.
Evelyn R. Smith, Katie L. Gelder, Lewis Hunter‐Craig, Daniel A. Bose, Timothy D. Craggs, Alison E. Twelvetrees   +5 more
wiley   +1 more source

Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18-30 Years Old): An Independent Post-Marketing Study. [PDF]

Pharmaceuticals (Basel), 2021
Riad A, Pokorná A, Klugarová J, Antalová N, Kantorová L, Koščík M, Klugar M.   +6 more
europepmc   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

The Efficacy and Tolerability of a Fixed Combination of Perindopril and Indapamide in the Treatment of Unregulated Essential Hypertension - a Postmarketing Study. [PDF]

Acta Med Acad, 2022
Šukalo A, Džananović Jaganjac J, Tanović Avdić A, Glamočlija U, Popović Ž, Boloban A, Tirić Čampara M, Mehić M.   +7 more
europepmc   +1 more source

MgP4/CNT‐Graphene Embedded in Hard Carbon Matrix as a High‐Capacity Anode for Next‐Generation Sodium‐Ion Batteries

Advanced Science, EarlyView.
Phosphorus‐rich MgP4 is introduced as a high capacity anode for sodium‐ion batteries (SIBs) via hybrid carbon matrix engineering. A sequential CNT/G assembly forms a conductive and mechanically robust network, delivering a high reversible capacity of 1386 mAh g−1 while stabilizing alloying reactions.
Sion Ha, Doyeon Lee, Dong Won Kim, Won‐Sik Kim, Minkyu Lee, Seong‐Hyeon Hong, Kyeong‐Ho Kim   +6 more
wiley   +1 more source

Patient-Reported Epigastric Symptom Dynamics During Trimebutine Maleate Treatment: A Post-Marketing Study. [PDF]

Medicina (Kaunas)
Stoev S, Yanachkova V, Petkova-Gueorguieva E, Gueorguiev S, Getova-Kolarova V, Lebanova H, Koynarski V.   +6 more
europepmc   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Safety and efficacy of a suction cervical stabilizer for IUD insertion: Results from a multicenter post-marketing study. [PDF]

Int J Gynaecol Obstet
Yaron M, Crofts V, Marcelino AC, Espejo-Arce X, Garcia E, Barbe J, Vilaplana EG, Murtas M, Juliato CT, Moussaoui D, Conklin A, Bahamondes L.   +11 more
europepmc   +1 more source

Safety and effectiveness of mirabegron in male patients with overactive bladder with or without benign prostatic hyperplasia: A Japanese post-marketing study. [PDF]

Low Urin Tract Symptoms, 2021
Takahashi S, Kato D, Tabuchi H, Uno S.
europepmc   +1 more source