Results 121 to 130 of about 80,572 (259)

Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy

Advanced Science, EarlyView.
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang, Shengxin Lu, Guangyong Zheng, Shensuo Li, Hongyu Chen, Mei Hong, Xiangru Zhou, Ruotian Tang, Ye Wu, Weidong Zhang, Dong Lu, Xin Luan   +11 more
wiley   +1 more source

Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18-30 Years Old): An Independent Post-Marketing Study. [PDF]

Pharmaceuticals (Basel), 2021
Riad A, Pokorná A, Klugarová J, Antalová N, Kantorová L, Koščík M, Klugar M.   +6 more
europepmc   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

The Efficacy and Tolerability of a Fixed Combination of Perindopril and Indapamide in the Treatment of Unregulated Essential Hypertension - a Postmarketing Study. [PDF]

Acta Med Acad, 2022
Šukalo A, Džananović Jaganjac J, Tanović Avdić A, Glamočlija U, Popović Ž, Boloban A, Tirić Čampara M, Mehić M.   +7 more
europepmc   +1 more source

Lactoferrin Deficiency During Lactation Causes Adult Obesity‐Related Metabolic Disease Through Persistent Adipose Dysfunction Driven by Impaired Adipocyte Development

Advanced Science, EarlyView.
Lactational lactoferrin deficiency exerts lasting effects on epididymal adipose tissue development from lactation into adulthood: it impairs adipocyte hyperplasia and induces pathological hypertrophy, resulting in lower body weight yet exacerbated metabolic dysfunction under a high‐fat diet in adulthood.
Qin An, Yunxia Zou, Wenli Wang, Zhimei Cheng, Zhuoxing Zhang, Ruwei Liu, Xiong Wang, Kunlun Huang, Fangrong Ding, Yunping Dai, Qingyong Meng, Yali Zhang   +11 more
wiley   +1 more source

Patient-Reported Epigastric Symptom Dynamics During Trimebutine Maleate Treatment: A Post-Marketing Study. [PDF]

Medicina (Kaunas)
Stoev S, Yanachkova V, Petkova-Gueorguieva E, Gueorguiev S, Getova-Kolarova V, Lebanova H, Koynarski V.   +6 more
europepmc   +1 more source

Fully Textured Monolithic Sb2S3/Silicon Tandem for Unbiased and Stable Solar‐Driven Water Splitting Paired with Iodide Oxidation Reaction

Advanced Science, EarlyView.
Monolithically integrated Sb2S3 on industry‐compatible textured silicon for tandem photoelectrochemical hydrogen evolution coupled with iodide oxidation. ABSTRACT Solar‐driven photoelectrochemical (PEC) production of chemical fuels such as hydrogen is a viable solution to address climate neutrality objectives.
Jihong Min, Irene Dei Tos, Sepideh Rahimisheikh, Beatriz de la Fuente, Devika Rajagopal, Jan D'Haen, David Cornil, Tom Hauffman, Tom Aernouts, David Beljonne, Joke Hadermann, Byungha Shin, Bart Vermang, Sudhanshu Shukla   +13 more
wiley   +1 more source

Safety and efficacy of a suction cervical stabilizer for IUD insertion: Results from a multicenter post-marketing study. [PDF]

Int J Gynaecol Obstet
Yaron M, Crofts V, Marcelino AC, Espejo-Arce X, Garcia E, Barbe J, Vilaplana EG, Murtas M, Juliato CT, Moussaoui D, Conklin A, Bahamondes L.   +11 more
europepmc   +1 more source

Safety and effectiveness of mirabegron in male patients with overactive bladder with or without benign prostatic hyperplasia: A Japanese post-marketing study. [PDF]

Low Urin Tract Symptoms, 2021
Takahashi S, Kato D, Tabuchi H, Uno S.
europepmc   +1 more source

Post marketing surveillance studies

Psychiatric Bulletin, 1994
openaire   +1 more source