Results 41 to 50 of about 547,915 (267)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
María Isabel: teatro, testimonio y violencia de género a los 50 años del Golpe en Chile
ConfluenzeThis article analyzes the play María Isabel, premiered at the GAM Cultural Center in Santiago, Chile, during the commemoration of the 50th anniversary of the Coup d’État.
Nicolás Roman González
doaj +1 more source
Revista de Estudios Sociales, 2016 This article analyzes the post-memory of grandchildren of former political prisoners who were imprisoned under the Chilean civic-military dictatorship. The participants in the study were 14 young people of an average age of 21.4 years, from the regions ...
Ximena Faúndez Abarca +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Vers une postmémoire de la traite et de l’esclavage ?
Carnets, 2017 This essay examines how the post-memory of the suffering caused by the slave trade is depicted in two novels, Beloved (Toni Morrison) and Humus (Fabienne Kanor).
Fabrice Schurmans
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Teksty Drugie, 2018 Review: Marta Tomczok, Czyja dzisiaj jest Zagłada? Retoryka – ideologia- popkultura [Who Does the Holocaust Belong to Today? Rhetoric – Ideology – Pop Culture], Instytut Badań Literackich, Warsaw 2017.
Barbara Czarnecka
doaj
Immagini pensanti. Post-memorie dell’Africa nel lungo-metraggio e nel corto-metraggio portoghese
Confluenze, 2020 The article is a reflection on the relationship between images and the evocation processes. In particular, the analysis of the artistic production of colonial post-memory questions the gaps of the Portuguese past in Africa and its official ...
Rebecca Saldanha
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source