Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen +4 more
wiley +1 more source
"Are We to Treat Human Nature as the Early Victorian Lady Treated Telegrams?" British and German Sexual Science, Investigations of Nature and the Fight Against Censorship, c. 1890-1940. [PDF]
Fisher K, Funke J.
europepmc +1 more source
Fiber energy harvesters offer unprecedented flexibility and a unique capacity for integration into commercial textiles, overcoming the limitations of bulky and rigid conventional devices. This review summarizes recent advances in fiber‐based energy harvesting and provides strategic outlooks to accelerate technological progress in the field. ABSTRACT As
Hanhwi Jang +8 more
wiley +1 more source
Disaster risk reduction and Evangelical Christianity: a case for pluriversality in practice. [PDF]
Watson SD.
europepmc +1 more source
An integrated approach combining mass spectrometry imaging, transcriptomics, and phylogenetic analysis facilitated the efficient identification of genes involved in gallotannin biosynthesis in Paeonia suffruticosa. As a result, a key UGT and several SCPL acyltransferases responsible for biosynthesizing pentagalloylglucose were successfully identified ...
Yushi Liu +4 more
wiley +1 more source
Friendship, hope and communication during second-wave and postfeminism: Gillian E. Hanscombe's <i>Between Friends</i> and Sally Rooney's <i>Conversations with Friends</i>. [PDF]
Anđelinić A.
europepmc +1 more source
Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai +7 more
wiley +1 more source
PATCH: A deep learning method to assess heterogeneity of artistic practice in historical paintings. [PDF]
Van Horn A +12 more
europepmc +1 more source

