Results 31 to 40 of about 1,306 (264)

The message in the bottle and 'perfect crack': Freestone of Danilo Kiš in the context of contemporary aesthetic and poetic studies [PDF]

open access: yesBaština, 2013
In the spirit of post-modernism, the Freestone is one of the pioneer novel which practically, by its form, and its essayistic course and meta-narrative commentaries contests a numerous totalistic 'great narrations' of our culture: calls into question the
Bečejski Mirjana
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

'Dialog with the father' or 'Paradoxal-ism': Modernism and post-modernism [PDF]

open access: yesBaština, 2012
Having relied on several capital oeuvres, and on some overviews of small-scale endeavoring to approach this problem in objective manner - aesthetic, literary- historical and culturological (sociological) studies/treaties on the relationship between ...
Bečejski Mirjana
doaj  

La Nueva Arquitectura y la Ciudad / The New Architecture and the City

open access: yesRevista de Urbanismo, 2002
Intentando soslayar la convencional confrontación dialéctica entre el Modernismo y el Post-Modernismo por parecer insuficiente y hoy sólo académica, este artículo refiere cuatro modelos que más que históricos son paradigmáticos, de modo de develar la ...
Munizaga Vigil, Gustavo
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Is a non-relativist post-modernism possible? The attempts of William Dean and Wentzel van Huyssteen

open access: yesHTS Teologiese Studies/Theological Studies, 1993
This paper aims at creating a third option to foundationalism and relativism. It criticizes William Dean’s historicist radical empiricism for going too far toward a relativ ist deconstructionism, and Wentzel van Huyss teen’s critical realism for not ...
J. A. Stone
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

The post-modern research system [PDF]

open access: yesScience and Public Policy, 1996
The landscape of science is changing radically. In particular, there is increasing heterogeneity of actors, research sites, knowledge and networks. Science policy-makers have to respond to these changes, but heterogeneity makes it more difficult to impose own goals on the research system.
Arie Rip, Barend J R van der Meulen
openaire   +3 more sources

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