Results 271 to 280 of about 4,473,179 (401)

Cytoprotection Concepts for Ischemic Stroke in the Recanalization Era

Advanced Science, EarlyView.
This review provides detailed information on modern cytoprotective strategies for ischemic stroke in the context of recanalization therapies. It derives their rationale based on contemporary knowledge of stroke pathophysiology and discusses the role of advanced imaging approaches as well as concepts for novel clinical trial designs.
Johannes Boltze, Marc Fisher
wiley   +1 more source

Sensing Heat, Finding Cool: The Search for Water in Summertime Paris, New York, and London, 1880-1930. [PDF]

J Soc Hist
Winder J, Duteil C, Schlichting K, Pearson C.   +3 more
europepmc   +1 more source

Da prática da eugenia na pós-modernidade em decorrência da utilização da reprodução humana assistida na realização do projeto parental = The practice of eugenics in the post-modernity through the assisted human reproduction in the realisation of the parental project

, 2015
Gorete Baptista, Marcela Gorete Rosa Maia Guerra   +1 more
openalex   +1 more source

Macrophage TRIM21 Inhibition Ameliorates Murine Acute Pancreatitis via PHB2‐Mediated Mitochondrial Stabilization

Advanced Science, EarlyView.
Macrophage‐derived TRIM21 drives the progression of AP via ubiquitin‐proteasome‐mediated degradation of PHB2, leading to impaired PHB2‐mediated mitophagy. Therefore, accumulation of cytosolic mtDNA hyperactivates the cGAS‐STING signaling axis, thereby amplifying inflammatory cascades.
Yansong Xu, Yuansong Sun, Xin Zhou, Kai Song, Chunlin Yin, Zhaohua Wang, Fei Xie, He Li   +7 more
wiley   +1 more source

The Knowledge-Attitude-Behavior Paradox in E-Cigarette Adoption Among University Students at Northern Border University, Saudi Arabia. [PDF]

J Multidiscip Healthc
Alenezi IN, Mersal FA, Osman Mohamed HA, El Said FG, Alanazi FJ, Abu-Negm LM, Aboelola TH, Alrwili AG.   +7 more
europepmc   +1 more source

Dialectics of post/colonial modernity in the Middle East: a critical, theoretical and disciplinary overview [PDF]

, 2018
Alan Ball, Karim Mattar
openalex  

Localized NF‐κB Inhibition Reduces Lipid Nanoparticle‐Associated Inflammation

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) activate NF‐κB and provoke inflammation that limits therapeutic delivery. By encapsulating selective NF‐κB inhibitors within LNPs, localized suppression of inflammatory signaling is achieved without compromising mRNA expression.
Carolann L. Espy, Jichuan Wu, Serena Omo‐Lamai, Liuqian Wang, Fengyi Dong, Aleksa Milosavljevic, Sarah O'Neill, Taylor Brysgel, Yufei Wang, Michael Zaleski, Emily Wolfe, Rhea Maheshwari, Manthan Patel, Dirk Trauner, Jia Nong, Zhicheng Wang, Jacob S. Brenner   +16 more
wiley   +1 more source

Materialities of the In/between: Drugs and Medical Knowledge between Europe and East Asia. [PDF]

Ber Wiss
Merdes D, Wahrig B.
europepmc   +1 more source

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source