Results 41 to 50 of about 26,731 (262)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Influence of husbandry and habitat design on Japanese giant salamander (Andrias japonicus) behavior and space use

Discover Animals
Complex, appropriately sized, and enriching environments that promote the expression of species-appropriate behaviors have been associated with positive welfare outcomes for many taxa.
Diana A. Palacios, Kylen N. Gartland, Michael Andrus, Mark Vassallo, Grace Fuller   +4 more
doaj   +1 more source

Post-Occupancy Evaluation of UK Library Building Projects: Some Examples of Current Activity

Liber Quarterly: The Journal of European Research Libraries, 2002
Post-occupancy evaluations of buildings ask questions and provide answers on how buildings actually work in technical, social and management terms for the end-users1.
Suzanne Enright
doaj   +1 more source

Post-Occupancy Evaluation of an educational building: Case study of the ETS-UESC Building

REM: International Engineering Journal, 2022
The physical and environmental conditions of educational institutions are determining factors for occupant comfort. The Post-Occupancy Evaluation (POE) presents itself as a methodology for verifying environmental aspects in full use, considering the ...
Thayse Gama de Carvalho, Suânia Fabiele Moitinho da Silva Reg, Maurício dos Santos Oliveira, Renan Leão Silva, Cleverson Alves de Lima, Vanessa de Freitas Cunha Lins   +5 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Post Occupancy Evaluation: Aquarium [PDF]

, 2010
Informal learning environments, such as aquaria, are attracting an increasingly diverse visitor population as the number of people with disabilities living in the community has grown. These environments are particularly important as they provide unique opportunities for visitors with disabilities to participate with friends and family in shared ...
openaire   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Identification of physical changes in dome house (Teletubies) Ngelepen Dusun, Prambanan with the Post Occupancy Evaluation (POE) approach

ARTEKS : Jurnal Teknik Arsitektur
A relocation of houses for the residents of Sengir hamlet, approximately 500 meters away from Nglepen hamlet, which was affected by the earthquake in 2006, the Dome House (Teletubbies) is the product of the participation of several donor countries and is
Rachmat Budiharjo, Soesilo Boedi Leksono
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source