Results 91 to 100 of about 10,520,983 (276)

Thermal Shifts Dominate Single‐Gene Responses to Transcription‐Targeting Antibiotics

Advanced Science, EarlyView.
Thermal shifts reshape bacterial responses to transcription‐targeting antibiotics. In E. coli, temperature can dominate antibiotic‐induced genome‐wide expression, particularly outside 30°C–39°C, through changes in adenosine triphosphate (ATP), nucleoid organization, and drug‐target engagement.
Rahul Jagadeesan, Amir M. Arsh, Vatsala Chauhan, Suchintak Dash, Pooja Ravaria, Andre S. Ribeiro   +5 more
wiley   +1 more source

Post-occupancy evaluation of library buildings

, 2015
Architectural realisation of a building and its opening to the public with a range of services are central components of the building and design process of libraries. Post-Occupancy Evaluation (POE) is the final step in this process.
IFLA Library Buildings and Equipment Section
core   +1 more source

Confirmatory factoral validity of public housing satisfaction constructs

Cogent Business & Management, 2017
Validation of housing satisfaction constructs using different perspectives is necessary with increasing relevance of Modelling in post occupancy evaluation (POE).
Bala Ishiyaku, Rozilah Kasim, Adamu Isa Harir   +2 more
doaj   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

Plug n Play: Future Prefab for Smart Green Schools

Buildings, 2018
While relocatable, prefabricated learning environments have formed an important component of school infrastructure in Australia, prefabrication for permanent school buildings is a new and emerging field.
Clare Newton, Sarah Backhouse, Ajibade A. Aibinu, Benjamin Cleveland, Robert H. Crawford, Dominik Holzer, Philippa Soccio, Thomas Kvan   +7 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Applying Post-Occupancy Evaluation (POE) to investigate inclusive design in library spaces. Case studies: Kharazmi, Main Library and Documentation Centre, and the Art and Architecture Libraries

Journal of Accessibility and Design for All
Inclusive architecture aims to create spaces that cater to everyone, regardless of their abilities or disabilities. Public libraries play a pivotal role in this endeavour by providing accessible environments for diverse communities. This study conducts a post-occupancy evaluation (POE) of the inclusivity of three libraries in Shiraz, examining how ...
Fathipour, Anis, Zakeri, Seyyed Mohammad Hossein, Nikkar, Mohammad   +2 more
openaire   +2 more sources

qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness

Advanced Science, EarlyView.
In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang, Ziyan Zhang, Swee Hong Ng, Haipeng Gong   +3 more
wiley   +1 more source

Results from a Post-Occupancy Evaluation of five primary schools

, 2009
Since 1998 several primary schools have been built in Coventry that follow the guidelines contained in a model brief developed by Coventry City Council.
Dunham, P., Newman, M.; id_orcid, Woodcock, A.; id_orcid   +2 more
core   +4 more sources

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source