Results 81 to 90 of about 4,009,203 (287)
Die mutasie van feit tot fiksie: die faksionele kode in 'Die jonkmanskas' van Koos Prinsloo
Literator, 1989 Documentary realism is a marked characteristic of Afrikaans literature in the eighties. This article looks critically at the techniques used by the author of the story “Die jonkmanskas” in his attempts to present an external, factual realm within a ...
R. Botha
doaj +1 more source
Animalistic Attributes to Humans in the Greek Post-war Prose: From Realism to Modernism
, 2023 Tasos Michailidis
openalex +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
L'inventario di un universo. Antropologia e letteratura in Corrado Alvaro
EtnoAntropologia, 2019 Some of Corrado Alvaro's works, especially those regarding Calabria, are often evaluated not only for their literary value, but also for their documentary value.
Fulvio Librandi
doaj +4 more sources
Metamodern in Indonesian Literature: A Night of 1,000 Traitors by Intan Paramaditha (2023) [PDF]
Studia LitterarumLooking at contemporary Indonesian literature through the lenses of the novel A Night of 1,000 Traitors by Intan Paramaditha (2023), one can explore the further development of so-called late postmodernism.
Marina V. Frolova
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
THE CHARACTER IMAGE OF RUSSIAN AND SOVIET CINEMA: FROM SOCIALIST REALISM MODEL TO UNCERTAINTY OF POST-SOVIET PERIOD [PDF]
, 2017 Veronika V. Sennikova +1 more
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source