Results 241 to 250 of about 233,946 (332)
Treosulfan–fludarabine conditioning in infants with severe combined immunodeficiencies: Extended study of the UK paediatric treosulfan study
British Journal of Haematology, Volume 208, Issue 5, Page 1713-1723, May 2026.Summary
Allogeneic haematopoietic stem cell transplantation (HSCT) is a curative therapy for severe combined immunodeficiency (SCID). Conditioning improves donor engraftment and freedom from immunoglobulin replacement (IgR) but increases the risks of acute and late toxicity. Treosulfan, a reduced toxicity alkylating agent, has emerged as an alternative Su Han Lum, Sinéad Greener, Irum Latif Memon, Persis Amrolia, Zohreh Nademi, Robert Chiesa, Juliana Silva, Helen Young, Stephen Owens, Eleri Williams, Khuen Foong Ng, Terry Flood, Andrew R Gennery, Sophie Hambleton, Kanchan Rao, Mary Slatter +15 morewiley +1 more sourceNovel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review
British Journal of Pharmacology, Volume 183, Issue 9, Page 1779-1813, May 2026.Abstract
In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy +16 morewiley +1 more sourceSplenectomy in β‐thalassemia patients: Practices and risks in a nationwide study
HemaSphere, Volume 10, Issue 5, May 2026.Audrey Benoit, Justine Pages, Sarah Szepetowski, Imane Agouti, Isabelle Thuret, Enora Le Roux, Catherine Badens, Valentine Brousse, NaThalY Network, Catherine Mathey, Louisa Bey, Marie‐Josée Lucchini, Valérie Li Thio Te, Reda Garidi, Loïc Garcon, Corentin Orvain, Jean‐François Brasme, Claire Reynes, Marie Belloy, Julie Durin, Oula Alhindy, Lara Sabbagh, Borhane Slama, Anthony Sanchez, Alice Moulin, Danielle Belgodere, Lise Benjemia, Pauline Simon, Eric Oziol, Nathalie Aladjidi, Yoann Huguenin, Charlotte Jubert, Edouard Forcade, Pierre Duffau, Abdallah Maakaroun, Florence Lachenal, Charline Pegon, Marie‐Helene Odievre, Charlotte Petitdidier, Sai Atmani, Florence Raqbi, Corinne Pondarre, Jenny Youn, Annie Kamdem, Dora Bachir, Pablo Bartolucci, Gonzalo De Luna, Anoosha Habibi, Elena Fois, Antoine Leblanc, Pierre‐Yves Dides, Caroline Makowski, Corinne Armari, Narcisse Elenga, Christelle Chantalat‐Auger, Françoise Driss, Ferielle Zenchri, Corinne Guitton, Mathilde Jehanne, Cecile Stoven, Axel Chaminade, Stephanie Gourdon, Yves Reguerre, Edouard Randriamalala, Véronique Paumier‐Bonjour, Anne Besancon‐Bergelin, Anne Lambilliotte, Benedicte Bruno, Fanny Gonzales, Melissa Barbati, Benjamin Carpentier, Christophe Piguet, Mohamed Touati, Arnaud Hot, Fiorenza Barraco, Giovanna Cannas, Emilie Virot, Romain Fort, Grégoire Ducoux, Hélène Desmurs Clavel, Kamila Kebaili, Nathalie Garnier, Cécile Renard, Yves Bertrand, Anne‐Laure Peugnet, Carine Halfon‐Domenech, Judith Diakiesse, Kokou‐Placide Agbo‐Kpati, Nathalie Ravet, Isabelle Thuret, Sarah Szepetowski, Estelle Jean, Benjamin De Sainte Marie, Benoit Meunier, Benoit Faucher, Matias Muszlak, Abdourahim Chamouine, Alain Garou, Caroline Masserot‐Lureau, Jean‐Marc Schneider, Veronique Dorvaux, Philippe Carassou, Honorat Andriamihaja, Muriel Lalande, Perrine Mahe, Anne Sirvent, Patricia Aguilar Martinez, Ivan Bertchansky, Jean‐Claude Eisenmann, Agathe Masseau, Marie‐Laure Couec, Fanny Rialland, Pierre‐Simon Rohrlich, Sandrine Baron‐Joly, Mohamed Conde, Antoine Dossier, Valentine Brousse, Karima Yakouben, Malika Benkerrou, Ghislaine Ithier, Florence Missud, Jean‐Hugues Dalle, Bérengène Koehl, Laurent Holvoet, Jean‐Antoine Ribeil, Laure Joseph, Marina Cavazzana, Marianne De Montalembert, Benedicte Neven, Despina Moshous, Mélissa Taylor, Slimane Allali, Bruno Varet, Gerard Socie, Alienor Xhaard, Régis Peffault De La Tour, Thierry Leblanc, Nicolas Boissel, Marie Robin, Nathalie Dhedin, Robert Girot, Sarah Mattioni, François Lionnet, Jean Donadieu, Guy Leverger, Sylvie Fasola, Jean‐Benoit Arlet, Corina Manoli, Maryse Etienne‐Julan, Emmanuelle Bernit, Justine Gellen‐Dautremer, Stéphanie Eyssette, Gilles Blondin, Claire Pluchart, Stanislas Nimubona, Jacinthe Bonneau, Sophie Bayart, Sophie Pertuisel, Benedicte Collet, Laurence Detourmignies, Julie Machin, Mathieu Wemeau, Laurence De Tourmigni, Jean‐Pierre Vannier, Bruno Filhon, Cecile Dumesnil, Agnes Lahary, Pascale Schneider, Stéphanie Ngo, Aurore Malric, Maud Schoeny, Claire Berger, Isabelle Guichard, Aurélie Desbree, Jean‐Louis Stephan, Audrey David, Catherine Paillard, Alexandra Salmon, Shanti Ame, Philippe Gestas, Marianne Besnard, Marie‐Pierre Castex, Geneviève Plat‐Wilson, Pierre Cougoul, Marlène Pasquet, Jill Serre, Marion Yvert, Jean‐Baptiste Valentin, Francis Duchene, Suzanne Mathieu, Marie Drouilly, Marie Detrait, Cécile Pochon, Aurélie Phulpin, Sylvie Nathanson +194 morewiley +1 more sourceCommon Gynecologic Issues in Patients Post‐Kidney Transplantation
Clinical Transplantation, Volume 40, Issue 5, May 2026.ABSTRACT
Advances in kidney transplantation have transformed survival and quality of life for women with end‐stage renal disease, necessitating a focus on long‐term health care for this population. Female kidney transplant recipients (KTR) experience a unique spectrum of gynecologic issues shaped by persistent hormonal dysregulation, lifelong ...Mary Elaine Graham, Janelle Moulder, Eva Reina, Oona O'Neill, Emily McCracken +4 morewiley +1 more sourceAspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis Among Patients With Post-Thrombotic Syndrome: The Multicenter, Multinational, Randomized, Open-Label ARIVA Trial. [PDF]
CirculationBarco S, Jalaie H, Sebastian T, Wolf S, Fumagalli RM, Lichtenberg M, Zeller T, Erbel C, Schlager O, Kucher N. +9 moreeuropepmc +1 more sourceOptimizing Oligonucleotide Therapeutics: A Model‐Informed Drug Development Perspective
Clinical and Translational Science, Volume 19, Issue 5, May 2026.ABSTRACT
Oligonucleotide therapies have emerged as a powerful therapeutic class, providing novel solutions for diverse diseases through antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), and aptamers that specifically target and modulate gene expression or protein function. However, oligonucleotide development faces distinct challenges,Ye Yuan, Vishnu Sharma, Venkatesh Atul Bhattaram, Xiaolei Pan, Justin Earp, Yun Wang, Jiang Liu, Hao Zhu +7 morewiley +1 more sourceAssociation between diabetes and in‐hospital outcomes in patients with metabolic dysfunction‐associated steatotic liver disease hospitalized for cardiovascular disease: A nationwide database study
Diabetic Medicine, Volume 43, Issue 5, May 2026.In a nationwide cohort of 10,614 patients with metabolic dysfunction–associated steatotic liver disease (MASLD) hospitalized for cardiovascular disease (CVD), diabetes was present in 4550 patients (43%) and was independently associated with higher in‐hospital mortality and cardiovascular complications.Soichi Komaki, Michikazu Nakai, Yunosuke Matsuura, Kinuko Yamamoto, Hiroki Tanaka, Yuri Komaki, Masashi Yamaguchi, Kohei Moribayashi, Takeshi Ideguchi, Hiroshi Kawakami, Toshihiro Tsuruda, Koichi Kaikita +11 morewiley +1 more source