Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim +10 more
wiley +1 more source
Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post-Translational Modification. [PDF]
Westerveld M +4 more
europepmc +1 more source
Facile Deep Brain Electrode Coating with MXene for Improved Electrode Performance
Facile dip‐coating of commercial carbon fiber electrodes with Ti3C2Tx MXene improves electrical conductivity, reduces impedance, and enables single‐neuron recordings in the rat hippocampus over four weeks. The coating maintains biocompatibility, minimizes inflammation, and remains MRI‐compatible.
Laura Kondrataviciute +5 more
wiley +1 more source
Ordered ATP hydrolysis in the Hsp90 chaperone is regulated by Aha1 and a conserved post-translational modification. [PDF]
Amoah DP +3 more
europepmc +1 more source
Dysbiosis May Trigger Autoimmune Diseases via Inappropriate Post-Translational Modification of Host Proteins [PDF]
Aaron Lerner +2 more
core +1 more source
A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker +5 more
wiley +1 more source
The post-translational modification O-GlcNAc is a sensor and regulator of metabolism. [PDF]
Morales MM, Pratt MR.
europepmc +1 more source
A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves
Passive epicardial sleeves are evaluated in 3D in‐silico heart models to reveal how sleeve geometry, stiffness, anisotropy, and metamaterial architecture influence cardiac mechanics after myocardial infarction. A continuum‐to‐auxetic design exploration shows that region‐specific mechanical engagement can reduce infarct bulging and modulate torsional ...
Vahid Naeini +8 more
wiley +1 more source
Integrating bulk RNA-seq, scRNA-seq, and spatial transcriptomics data to identify novel post-translational modification-related molecular subtypes and therapeutic responses in hepatocellular carcinoma. [PDF]
Chen S +9 more
europepmc +1 more source

