Results 321 to 330 of about 541,798 (360)

Engineering Bacterial Secretion Systems for Enhanced Tumor Imaging and Surgical Guidance

Advanced Materials, EarlyView.
This study presents a novel contrast agent platform, Streptavidin Associated Salmonella (SAS), for fluorescence image guided surgery. SAS selectively colonizes tumors and secretes streptavidin, enabling precise delineation of invasive tumor margins with prolonged signal retention.
Dohee Lee, Heung Jin Jeon, Dohyub Jang, Deukhee Lee, Solbi Kim, Minju Han, Sharon Jiyoon Jung, Jung‐Hyun Lee, Jia Choi, Dong Ha Kim, Dong June Ahn, Keri Kim, Sehoon Kim, Hyo‐Jin Lee, SeungBeum Suh   +14 more
wiley   +1 more source

Post-translational modifications of p65: state of the art. [PDF]

Front Cell Dev Biol
Sun X, Cao S, Mao C, Sun F, Zhang X, Song Y.   +5 more
europepmc   +1 more source

Enhanced Deformability Through Distributed Buckling in Stiff Quasicrystalline Architected Materials

Advanced Materials, EarlyView.
Quasi‐periodic metamaterials combine stiffness and large‐strain deformability, overcoming limitations of traditional stretching‐dominated periodic designs that are prone to global buckling instabilities and catastrophic layer collapses. By leveraging non‐uniform force chains, they achieve high isotropic stiffness, stable deformation, and remarkable ...
Matheus I. N. Rosa, Konstantinos Karapiperis, Kaoutar Radi, Elias Pescialli, Dennis M. Kochmann   +4 more
wiley   +1 more source

Pan-PTM profiling identifies post-translational modifications associated with exceptional longevity and preservation of skeletal muscle function in Drosophila. [PDF]

NPJ Aging
Poudel S, Chuang CL, Shrestha HK, Demontis F.   +3 more
europepmc   +1 more source

Natural Design of a Stabilized Cross‐β Fold: Structure of the FuA FapC from Pseudomonas Sp. UK4 Reveals a Critical Role for Stacking of Imperfect Repeats

Advanced Materials, EarlyView.
We report a 3.2 Å cryoEM structure of functional amyloid protein FapC from Pseudomonas sp. UK4, an essential component of bacterial biofilm, which reveals a Greek key‐shaped protofilament, supports bioinformatically determined motifs, nuances AlphaFold predictions, emphasizes heterogeneous cross‐β stacking in amyloid cross‐seeding and shows strain ...
Yanting Jiang, Samuel Peña‐Díaz, Zhefei Zhang, Anders Ogechi Hostrup Daugberg, Marcos López Hernández, Janni Nielsen, Qiaojie Huang, Shenghan Qin, Morten K. D. Dueholm, Mingdong Dong, Jan Skov Pedersen, Qin Cao, Daniel E. Otzen, Huabing Wang   +13 more
wiley   +1 more source

Post-Translational Modifications of RNA-Modifying Proteins in Cellular Dynamics and Disease Progression. [PDF]

Adv Sci (Weinh)
Lin Y, Lin P, Lu Y, Zheng J, Zheng Y, Huang X, Zhao X, Cui L.   +7 more
europepmc   +1 more source

Reengineering Endogenous Targeting Lipid Nanoparticles (ENDO) for Systemic Delivery of mRNA to Pancreas

Advanced Materials, EarlyView.
ENDO lipid nanoparticles containing cholecalciferol as a fifth component demonstrate mRNA delivery to the pancreas with 99% selectivity, including beta cells. This platform shows minimal toxicity and sustained protein expression for up to 3 days in a dose‐dependent manner, offering a novel approach to pancreas‐specific mRNA delivery and gene therapy ...
Ivan Isaac, Luv Patel, Nguyen Tran, Amarnath Singam, DongSoo Yun, Prasun Guha, Seungman Park, Chandrabali Bhattacharya   +7 more
wiley   +1 more source

Relative quantification of proteins and post-translational modifications in proteomic experiments with shared peptides: a weight-based approach. [PDF]

Bioinformatics
Staniak M, Huang T, Figueroa-Navedo AM, Kohler D, Choi M, Hinkle T, Kleinheinz T, Blake R, Rose CM, Xu Y, Jean Beltran PM, Xue L, Bogdan M, Vitek O.   +13 more
europepmc   +1 more source

Adaptable Alchemy: Exploring the Flexibility of Specialized Metabolites to Environmental Perturbations Through Post-Translational Modifications (PTMs). [PDF]

Plants (Basel)
Cimmino L, Staiti A, Carputo D, Docimo T, D'Amelia V, Aversano R.   +5 more
europepmc   +1 more source