Results 101 to 110 of about 276,389 (232)

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Multifunctional Biomimetic Nanotherapeutics for Anti‐Oxidative and Anti‐Inflammatory Synergistic Therapy of Corneal Neovascularization

Aggregate, EarlyView.
An anti‐inflammatory and antioxidant metal‐organic framework (MOF) nanoplatform was prepared via one‐pot self‐assembly. In vitro and in vivo studies demonstrated that the prepared MVPC nanoparticles can effectively scavenge overproduced reactive oxygen species at diseased sites, enhance IL‐10 secretion, and suppress VEGFA expression, offering a novel ...
Shundong Cai, Mengdie Li, Jinfa Ye, Mingyou Zhang, Jingbin Zhuang, Yuhang Cheng, Hongjin Li, Lang Ke, Xingyuan Wei, Yun Han, Huanhuan Liu, Gang Liu, Chengchao Chu   +12 more
wiley   +1 more source

Artificial Intelligences: A Bridge Toward Diverse Intelligence and Humanity's Future

Advanced Intelligent Systems, EarlyView.
Many discussions of artificial intelligence fail to address deeper questions being raised by advances in developmental biology, neuroscience, bioengineering, and philosophy of mind. Novel beings, including technologically and biologically augmented humans, engineered life forms, hybrots, and others, require tools of the emerging field of diverse ...
Michael Levin
wiley   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

Social support for veterans taking part in military service outside their country’s borders [PDF]

, 2019
Soldiers who return to their country of residence after military service are subject to numerous, mostly negative, effects linked to exposure to stress.
Goniewicz, Krzysztof, Mendrek, Paulina, Osiak, Beata   +2 more
core   +1 more source

Promoting radical healing to facilitate community capacity building among formerly incarcerated Black and Latino men with substance use disorders

American Journal of Community Psychology, EarlyView.
Abstract This study reports on a qualitative thematic analysis of secondary data from group session recordings collected as part of the Community Wise Optimization Trial. Community Wise is a multilevel behavioral intervention designed to increase critical consciousness and reduce substance use among formerly incarcerated men living in predominantly ...
Richmond E. Hayes, Heather A. Jones, Ellen Benoit, Dora N. Watkins, Liliane C. Windsor   +4 more
wiley   +1 more source

A companion to the preclinical common data elements for proteomics, lipidomics, and metabolomics data in rodent epilepsy models. A report of the TASK3‐WG4 omics working group of the ILAE/AES joint translational TASK force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various preclinical epilepsy research disciplines.
Laura Bindila, Tore Eid, James D. Mills, Michael S. Hildebrand, Gary P. Brennan, Susan A. Masino, Vicky Whittemore, Piero Perucca, Christopher A. Reid, Manisha Patel, Kevin K. Wang, Erwin A. van Vliet   +11 more
wiley   +1 more source

Post-Traumatic Stress and Academic Performance Among Entry-Level Doctoral Physical Therapy Students in a Human Anatomy Cadaver Dissection Course [PDF]

, 2018
Background: Dissection of human cadavers can be a stressful experience for students. Purpose: The purposes of this study were twofold: 1) to determine if physical therapy students develop or experience a worsening of post-traumatic stress disorder (PTSD)
Austin, Gary P, Curfman, Sue E, Nicholas, Joyce S   +2 more
core   +1 more source

‘I Don't Think I Would've Survived Without Having a Constant Support System’: Independent Living Skills Acquisition During the Transition From Care in Western Australia

Australian Journal of Social Issues, EarlyView.
ABSTRACT For care‐experienced young people, the preparation for leaving out‐of‐home care (OOHC) is vital in support of post‐OOHC outcomes. This research explores the acquisition of Independent Living Skills (ILS) amongst young people in Western Australia and is based on interviews with care‐experienced young people at two time points: while in OOHC and
Michael Starr, Donna Chung, Lauren Parsons, Reinie Cordier   +3 more
wiley   +1 more source

A companion to the preclinical common data elements for phenotyping seizures and epilepsy in rodent models. A report of the TASK3‐WG1C: Phenotyping working group of the ILAE/AES joint translational task force

Epilepsia Open, EarlyView., 2022
Abstract Epilepsy is a heterogeneous disorder characterized by spontaneous seizures and behavioral comorbidities. The underlying mechanisms of seizures and epilepsy across various syndromes lead to diverse clinical presentation and features. Similarly, animal models of epilepsy arise from numerous dissimilar inciting events.
Melissa Barker‐Haliski, Julika Pitsch, Aristea S. Galanopoulou, Rüdiger Köhling   +3 more
wiley   +1 more source