Post-Treatment Lyme Disease Syndrome: Need for Diagnosis and Treatment [PDF]
Cureus, 2021 With the continued surge in Lyme disease cases, post-treatment Lyme disease syndrome (PTLDS) is becoming a more pressing health concern. The aim of this review is to identify comprehensive treatment strategies for PTLDS patients. Unfortunately, universal guidelines for diagnosing and treating PTLDS do not currently exist.
Maksimyan, Simona +2 more
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Reassessing Chronic Lyme Disease and Post-Treatment Lyme Disease Syndrome as Focal Infections [PDF]
CureusThe complete clinical spectrum of Lyme borreliosis has been recognized for nearly 50 years, yet its diagnosis remains challenging due to the heterogeneity of symptoms. While many symptoms are likely nonspecific, a recurring cluster, including severe fatigue, brain fog, cognitive decline, memory impairment, joint and muscle pain, limb numbness ...
Lakos, András +4 more
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Effects of intravenous ketamine in a patient with post-treatment Lyme disease syndrome [PDF]
International Medical Case Reports Journal, 2017 Post-treatment Lyme disease syndrome (PTLDS) is a pain disorder for which there remains no gold standard treatment option. Here, we report a case of PTLDS in a female patient whose pain was refractory to treatment options such as radiofrequency ablation, vitamin infusion therapy, opioid analgesics, and other pharmacotherapies.
Hanna, Ashraf F +3 more
europepmc +8 more sources
Non-specific symptoms and post-treatment Lyme disease syndrome in patients with Lyme borreliosis: a prospective cohort study in Belgium (2016–2020) [PDF]
BMC Infectious Diseases, 2022 Abstract Background Patients with Lyme borreliosis (LB) may report persisting non-specific symptoms such as fatigue, widespread musculoskeletal pain or cognitive difficulties. When present for more than 6 months and causing a reduction in daily activities, this is often referred to as post-treatment Lyme disease syndrome
Geebelen, Laurence +22 more
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Development of a foundation for a case definition of post-treatment Lyme disease syndrome [PDF]
International Journal of Infectious Diseases, 2013 The study objective is to demonstrate the clinical and research utility of an operationalized definition of post-treatment Lyme disease syndrome (PTLDS), as proposed by the Infectious Diseases Society of America.Seventy-four patients with confirmed erythema migrans and 14 controls were enrolled.
John N Aucott, Lauren A Crowder
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Association of small fiber neuropathy and post treatment Lyme disease syndrome [PDF]
PLOS ONE, 2019 To examine whether post-treatment Lyme disease syndrome (PTLDS) defined by fatigue, cognitive complaints and widespread pain following the treatment of Lyme disease is associated with small fiber neuropathy (SFN) manifesting as autonomic and sensory dysfunction.This single center, retrospective study evaluated subjects with PTLDS.
Peter Novak +4 more
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What Makes It Tick: Exploring the Mechanisms of Post-treatment Lyme Disease Syndrome [PDF]
CureusPost-treatment Lyme disease syndrome (PTLDS), which may also be referred to incorrectly as "chronic Lyme disease," is defined by the Infectious Diseases Society of America (IDSA) as the presence of fatigue, pain, and/or cognitive complaints with the functional impact that persists for more than six months after completing treatment for Lyme disease (LD)
Wester, Kate E +6 more
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A Reappraisal of the U.S. Clinical Trials of Post-Treatment Lyme Disease Syndrome [PDF]
The Open Neurology Journal, 2012 Four federally funded randomized placebo-controlled treatment trials of post-treatment Lyme syndrome in the United States have been conducted. Most international treatment guidelines summarize these trials as having shown no acute or sustained benefit to repeated antibiotic therapy.
Fallon, Brian A. +3 more
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Development of Low-Dose Disulfiram Rectal Suppository Intended for Application in Post-Treatment Lyme Disease Syndrome [PDF]
PharmaceuticsBackground/Objectives: Early diagnosis and oral or, in severe cases, intravenous antibiotics are usually effective for Lyme disease, but some patients have persistent symptoms unresponsive to standards of care, requiring alternative therapies. Disulfiram (DIS), a drug for alcoholism, is under investigation as a potential adjunctive treatment, but its ...
Beáta-Mária Benkő +8 more
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The HUMTICK study: protocol for a prospective cohort study on post-treatment Lyme disease syndrome and the disease and cost burden of Lyme borreliosis in Belgium [PDF]
Archives of Public Health, 2017 In Belgium, different routine surveillance systems are in place to follow-up Lyme borreliosis trends. However, accurate data on the disease and monetary burden for the different clinical manifestations are lacking. Despite recommended antibiotic treatment, a proportion of Lyme patients report persisting aspecific symptoms for six months or more (e.g ...
Geebelen, Laurence +8 more
openaire +8 more sources