Results 61 to 70 of about 84,522 (243)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Problem Relativisme Kebenaran di Era Post-Truth: Tinjauan Epistemologis

Jurnal Yaqzhan: Analisis Filsafat, Agama dan Kemanusiaan
Artikel ini akan mengkaji teori kebenaran yang cukup kuat di antara tokoh post-modern, yaitu teori Dekonstruksi Sastra Jacques Derrida dan teori “Truth and Power” oleh Michel Foucault. Keduaya berpengaruh kuat pada pekembangan post-truth, setidaknya pada
Muhammad Faqih Nidzom, Fahmi Faujar Syam
doaj   +1 more source

ANALISIS PROFESIONALISME JURNALIS BERITAGAR.ID DI ERA POST TRUTH

Lektur, 2019
Penelitian ini menggunakan metode kualitatif pendekatan fenomenologi untuk mengeksplorasi pengalaman profesional jurnalis Beritagar.id, sehingga pengalaman itu memberi kontribusi pada profesionalisme di era post truth. Hasil penelitian menunjukkan bahwa:
Rima Trisnayanti, Dyna Herlina Suwarto
doaj   +1 more source

A Genealogy for Post-Truth Democracies: Philosophy, Affects, Technology

Communication & Society (Formerly Comunicación y Sociedad), 2020
How to make sense of post-truth? As the erosion of truth seems to be on the rise in contemporary societies, apparently threatening the deliberative function assigned to their public spheres and the health of democratic systems, it has become a necessity ...
Manuel Arias-Maldonado
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The scarlet letter of “post-truth”: the sunset boulevard of communication

Church, Communication and Culture, 2019
In this paper post-truth mechanisms in discourse are taken into account and the attempt is made to understand how language is used in communication characterized by post-truth.
Giovanni Gobber
doaj   +1 more source

Ideology and Truth: The Return of the Old Couple in the Post-Truth Era

Političke Perspektive, 2018
The author argues that any discourse analysis, as well as other approaches in social sciences and humanities, cannot ultimately avoid the truth and ideology distinction. The first part of the article provides several glimpses at the Western philosophical
Krešimir Petković
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source