Results 31 to 40 of about 1,306 (265)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Il design tra persuasione e retorica. Riflessioni a margine di Peter Sloterdijk [PDF]

open access: yesS&F_scienzaefilosofia.it, 2017
Design between Persuasion and Rhetoric. Footnotes to Peter Sloterdijk What is design? In this article we’ll try to explain how design is a phenomena of contemporary world, as an expression of the power typical of human being.
SCOTTI, ALESSANDRA
doaj  

A Study on the Figurative Sculptures from the Islamic Revolution to the End of the Iran-Iraq War with Regard to the Modernism [PDF]

open access: yesنگره, 2016
The main stream art in Iran following the revolution till the end of the Iran-Iraq war is religious in nature and committed to the values of the Islamic revolution. Despite the  ignorance or disapproval towards the pre-revolutionary artistic achievements,
mina talaei, fahimeh daneshghar
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

The message in the bottle and 'perfect crack': Freestone of Danilo Kiš in the context of contemporary aesthetic and poetic studies [PDF]

open access: yesBaština, 2013
In the spirit of post-modernism, the Freestone is one of the pioneer novel which practically, by its form, and its essayistic course and meta-narrative commentaries contests a numerous totalistic 'great narrations' of our culture: calls into question the
Bečejski Mirjana
doaj  

Forms of post-modernism in performance of Iraqi theatre "dream of Baghdad exam"

open access: yesالاكاديمي, 2021
The effects of postmodernism on theatrical form was managed by the director (Anas Abdul Samad) to be employed in the Iraqi play (Dream in Baghdad) and the researcher sought to study this problem and divided it into four chapters dealt with in the first ...
Amaar Abed Salman Mohamed
doaj   +1 more source

Constitutionalism's Post-Modern Opening [PDF]

open access: yes, 2008
AbstractThis chapter focuses on the radical potential of contemporary constitutionalism, whereby constituent power is neither colonized by nor in symbiosis with the legal. This potential is illustrated in the work of Negri, in which it remains a latent revolutionary possibility which lies behind the legally constituted authority of the polity.
openaire   +3 more sources

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

open access: yesFEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda   +4 more
wiley   +1 more source

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