Results 101 to 110 of about 1,455,570 (291)
Digital Geography and SocietyThrough the analysis of workers' experiences at different points in the logistics chain, we aim to demonstrate how platformization is a phenomenon with homogeneous and common impacts across different stages, and how algorithmic control shapes a ...
Francisco Fernández-Trujillo +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
, 2017 This short paper focusses on several aspects of the enforcement practices of compliance offices and labour inspections: Experiences of labour inspections; Fraud practices and mechanisms in posting; Cooperation across institutions and social partners; Redress, effective enforcement and prevention of fraud.
openaire +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
School For Christian Workers Seventh Commencement Program (June 1893)
, 1893 This is a program from the 1893 Commencement Exercises held at the School for Christian Workers. At the time of this commencement the School for Christian Workers had already split from the International YMCA Training School, now Springfield College. The
School for Christian Workers (Springfield, Mass.); Martin, Luther;
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Edukasi Penerapan Personal Higiene pada Pekerja dan Sanitasi Depot Air Minum Isi Ulang
Warta Pengabdian AndalasThere has been an increase in the number of refilled drinking water depots (DAMIU) yearly because they answer most people's needs in urban areas. Implementing hygiene and sanitation management at DAMIU is critical because it affects the quality of ...
Fea Firdani +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Appointing Foxes to Guard Henhouses : The European Posted Workers' Directive [PDF]
, 2008 This note addresses certain complications inherent in governance with regards to posted workers, i.e. workers posted on a temporary basis from one Member State of the Union to another, for the provision of services in the host Member State. In particular,
Ganesh, Aravind, Ganesh, A.
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