YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
The Addition of Posterolateral Tenodesis in Isolated PCL Injuries and in Combination With Fanelli Type A Lesion of the Posterolateral Corner Decreases Rotatory Instability: A Biomechanical Study in Human Cadaveric Knees. [PDF]
Orthop J Sports MedMorales-Avalos R +10 more
europepmc +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Estimating the Frequency of an Elongated Styloid Process of the Temporal Bone Along With its Anatomical Variations in Length Using Three-Dimensional Computerized Tomography. [PDF]
CureusSagar S, Ravi KS, Meena BK, Modwal A.
europepmc +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Posterior Decompression by Posterior Approach for Ossification of Posterior Longitudinal Ligament
Orthopedics & Traumatology, 2008 Yamada, Kei +8 more
openaire +3 more sources
IOL Calculators Variability in Toric Lens Planning: A Retrospective Paired Comparison of the Planning Discrepancies Between the Johnson & Johnson Toric Calculator and ESCRS-Hosted Engines. [PDF]
Clin OphthalmolKlimek M +5 more
europepmc +1 more source
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source