Results 111 to 120 of about 12,657,814 (311)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Surgical options for ossification of the posterior longitudinal ligament of the cervical spine: a narrative review

Journal of Orthopaedic Surgery and Research
Ossification of the posterior longitudinal ligament of the cervical spine (C-OPLL) is a degenerative disorder that leads to the narrowing of the spinal canal and compression of both the spinal cord and nerve roots.
Ningxue Sun, Chang Jiang, Yang Liu
doaj   +1 more source

Efficient MCMC and posterior consistency for Bayesian inverse problems [PDF]

Many mathematical models used in science and technology often contain parameters that are not known a priori. In order to match a model to a physical phenomenon, the parameters have to be adapted on the basis of the available data.
Vollmer, Sebastian
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Combined Direct Posterior Split-Gastrocnemius Approach for the Posterolateral Tibial Plateau Involved Fractures

, 2019
Changhong Chen,1,2 Lei Huang,2 Huaqing Zheng,2 Lin Liu,2 Yaofei Chen,1 Xinhui Xie,1 Yuntao Wang1 1Department of Orthopedics, Affiliated Zhongda Hospital of Southeast University, Nanjing, Jiangsu 210009, People’s Republic of China; 2Department of ...
Zheng H, Liu L, Xie X, Chen Y, Huang L, Chen C, Wang Y   +6 more
core  

Use of posterior predictive assessments to evaluate model fit in multilevel logistic regression [PDF]

, 2009
Assessing the fit of a model is an important final step in any statistical analysis, but this is not straightforward when complex discrete response models are used.
Browne, W. J., William J. Browne, Medley, GF, Martin J. Green, Green, Martin J., Medley, Graham, Green, MJ, Graham F. Medley, Green, M. J., Medley, Graham F., Browne, William J., Browne, WJ   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Comparative evaluation of “closed posterior levator advancement” in simple congenital and aponeurotic ptosis

Taiwan Journal of Ophthalmology
PURPOSE: The purpose of this study was to compare the outcomes of “closed posterior levator advancement” (CPLA) in acquired aponeurotic and simple congenital ptosis with good levator function (LF).
Ruchi Goel, Sonam Singh, Shalin Shah, Samreen Khanam, Priyanka Golhait, Tanvi Gaonker   +5 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source