Results 181 to 190 of about 12,657,814 (311)

Comparing dynamic equilibrium economies to data [PDF]

This paper studies the properties of the Bayesian approach to estimation and comparison of dynamic equilibrium economies. Both tasks can be performed even if the models are nonnested, misspecified, and nonlinear.
Jesus Fernández-Villaverde, Juan F. Rubio-Ramírez   +1 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Posterior Sacroiliac Joint Fusion for Severe Sacroiliac Joint Disorders: A Technical Note on Surgery Using Transarticular Cylindrical Cages Combining Posterior Instrumentation and its Surgical Outcomes

Spine Surgery and Related Research
Introduction: Anterior sacroiliac joint (SIJ) fusion has been performed for severe SIJ disorders and has demonstrated stable long-term outcomes; however, its relatively high invasiveness remains a significant concern.
Daisuke Kurosawa, Eiichi Murakami, Takeshi Sasaki, Hiroshi Ozawa   +3 more
doaj  

The evolution of the posterior approach in hip surgery: Back to Langenbeck. [PDF]

Langenbecks Arch Surg
de Boer DR, Munnik-Hagewoud R, IJpma FFA, van Driel PBAA, Ettema HB.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Modified Posterior Approach for Scapular Body Non-union: A Case Report. [PDF]

J Orthop Case Rep
Kumar D, Bansal A, Pydi SSD, Harshith M, Sharma K, Biswas P.   +5 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

A prospective study of anterior versus posterior approach for traumatic thoracolumbar fractures: A systemic review. [PDF]

J Craniovertebr Junction Spine
Ranade D, Lachake AS, Aziz R.
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source