Results 71 to 80 of about 1,105,008 (303)

Posterior Cervical Spine Crisscross Fixation: Biomechanical Evaluation [PDF]

, 2018
Background Biomechanical/anatomic limitations may limit the successful implantation, maintenance, and risk acceptance of posterior cervical plate/rod fixation for one stage decompression-fusion.
Cheng, Joseph S., Lifshutz, Jason I., Yoganandan, Narayan, Pintar, Frank A., Cusick, Joseph F.   +4 more
core  

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Fixation of the Sacroiliac Joint: A Cadaver-Based Concurrent-Controlled Biomechanical Comparison of Posterior Interposition and Posterolateral Transosseous Techniques [PDF]

Neurospine
Objective Our study aimed to compare the posterior interposition technique against the posterolateral transosseous technique in the same cadaver specimens. Methods Computer and cadaver models of 2 fixation techniques were developed.
Oluwatodimu Richard Raji, Jason E. Pope, Steven M. Falowski, Michael Stoffman, Jeremi M. Leasure   +4 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Single-Stage Hybrid Fixation of a Grade III Open, Unstable Trimalleolar Ankle Fracture with Syndesmotic Disruption and Posterior Talar Subluxation

Introduction: Trimalleolar ankle fractures, which involve syndesmotic damage and talar subluxation, are serious injuries that are complicated by open wounds.
Shailesh Kumar, Naveen Kumar Duraisamy, C S Likhit, D Sudharsan, K Purushothaman, Jeff Walter Rajadurai OR   +5 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Arthroscopic Posterior Glenoid Fracture Fixation Using Knotless Suture Anchors. [PDF]

, 2017
Shoulder instability after a posterior glenoid rim fracture is rare and potentially difficult pathology to treat. Operative techniques often involve a large dissection to view the fragments resulting in local soft tissue injury.
Tyler, J, Baxter, JA, Magnus Arnander, F.R.C.S.(Orth), Eyiyemi Pearse, F.R.C.S.(Orth), Arnander, M, Bhamber, N, Eyiyemi Pearse, James Tyler, Tennent, D, Duncan Tennent, Magnus Arnander, Nivander Bhamber, Pearse, E, Jonathan A. Baxter, Jonathan A. Baxter, F.R.C.S.(Orth), Nivander Bhamber, M.R.C.S., James Tyler, F.R.C.S.(Orth), Duncan Tennent, F.R.C.S.(Orth)   +17 more
core   +1 more source

The Role of Combined Anterior Retropharyngeal Approach and Posterior Fixation in Surgical Treatment of Upper Cervical Lesions

Egyptian Spine Journal, 2015
Background Data: Surgical exposure of the upper cervical spine is considered difficult due to the presence of essential and vital nearby structures. Anterior retropharyngeal approach provides direct and wide exposure to treat different lesions in the ...
Ahmed El-Kholy, Ebrahim Shamhoot
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source