Results 231 to 240 of about 10,323 (277)

The Landscape and Regulation of Histone Crotonylation in Mammalian Gametes and Early Embryos

open access: yesAdvanced Science, EarlyView.
Histone crotonylation undergoes a genome‐wide transition from broad domains to canonical narrow peaks during minor zygotic genome activation (ZGA). This remodeling is required for proper major ZGA and blastocyst formation. Disruption of this transition by transcriptional inhibition, metabolic perturbation, or HDAC1 dysfunction impairs embryonic ...
Shenli Yuan   +8 more
wiley   +1 more source

Open-Globe Injuries With Retained Intraocular Foreign Bodies: Anesthesia Options and Endophthalmitis Rates. [PDF]

open access: yesJ Vitreoretin Dis
Rohowetz LJ   +6 more
europepmc   +1 more source

Firefighters And Their Occupational Loads [PDF]

open access: yes, 2019
Dawes, Jay   +3 more
core  

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

open access: yesAdvanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang   +12 more
wiley   +1 more source

Mechanosensitive Piezo1/Osteocalcin/Irisin Axis Protects Against Disuse‐Induced Muscle Atrophy

open access: yesAdvanced Science, EarlyView.
Mechanical unloading suppresses bone Piezo1 expression, which reduces circulating undercarboxylated osteocalcin (unOCN). unOCN reduction subsequently exacerbates IMM‐induced Fndc5/Irisin decrease and drives severe muscle atrophy. Bone Piezo1 activation or exogenous osteocalcin/Irisin ameliorate muscle atrophy, while muscle‐specific Gprc6a or Fndc5 ...
Zhaolu Wang   +5 more
wiley   +1 more source

High-Pressure Water Jet Ocular Injuries during Riot Control: A Case Series. [PDF]

open access: yesCase Rep Ophthalmol
Cohen R   +7 more
europepmc   +1 more source

Appearance-based or health-based message framing: what motivates physical activity participation? [PDF]

open access: yes, 2019
Canetti, Elisa   +4 more
core  

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