Results 91 to 100 of about 208,751 (374)

Fixel‐Based Analysis of Diffusion Imaging as a Quantitative Marker of Disease State in Spinocerebellar Ataxia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxias (SCAs) are a group of genetically heterogeneous neurodegenerative diseases causing progressive deterioration and reduced quality of life. Therapeutic advances have been limited by a lack of sensitive anatomic, functional, or diffusion imaging‐based biomarkers.
David J. Arpin, S. H. Subramony, the READISCA Consortium, David E. Vaillancourt, Tetsuo Ashizawa, Alexandra Durr, Thomas Mareci, Thomas Klockgether, Jennifer Faber, Henry L. Paulson, Gülin Öz, Matthew R. Burns   +11 more
wiley   +1 more source

Understanding Mechanisms of Whole Brain and Regional Grey Matter Atrophy in Children With MOGAD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the mechanisms driving whole brain and regional grey matter (GM) volume changes along with their clinical correlates in paediatric myelin oligodendrocyte glycoprotein antibody (MOG‐Ab)–associated disease (MOGAD). Methods One‐hundred‐nine paediatric MOGAD patients from two UK centres underwent MRI at attack nadir and ...
Ermelinda De Meo, Riccardo Nistri, Michael Eyre, Cheryl Hemingway, Ming Lim, Thomas Rossor, Asthik Biswas, Kshitij Mankad, Ata Siddiqui, Sniya Sudhakar, Declan Chard, Frederik Barkhof, Arman Eshaghi, Olga Ciccarelli, Yael Hacohen   +14 more
wiley   +1 more source

Cognition in Sensorimotor Control: Interfacing With the Posterior Parietal Cortex [PDF]

Frontiers in Neuroscience, 2019
Millions of people worldwide are afflicted with paralysis from a disruption of neural pathways between the brain and the muscles. Because their cortical architecture is often preserved, these patients are able to plan movements despite an inability to execute them.
Chivukula, Srinivas, Jafari, Matiar, Aflalo, Tyson, Yong, Nicholas Au, Pouratian, Nader   +4 more
openaire   +6 more sources

Identification of Dementia With Lewy Bodies by Skin Biopsy in Recent‐Onset Cognitive Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Immunofluorescence for phosphorylated alpha‐synuclein in skin biopsy samples is an emerging biomarker in synucleinopathies comprising Dementia with Lewy bodies. In this pilot study, 19 patients with recent‐onset (≤ 18 months) cognitive impairment underwent skin biopsy at baseline, with follow‐up clinical re‐evaluation.
Alessandro Furia, Alex Incensi, Cecilia Delprete, Giovanni Rizzo, Salvatore Bonvegna, Marco Piatti, Enrica Olivola, Francesco Ventruto, Veria Vacchiano, Enrico Fileccia, Roberto Cilia, Nicola Modugno, Rocco Liguori, Vincenzo Donadio   +13 more
wiley   +1 more source

Enhanced Working Memory Binding by Direct Electrical Stimulation of the Parietal Cortex

Frontiers in Aging Neuroscience, 2017
Recent works evince the critical role of visual short-term memory (STM) binding deficits as a clinical and preclinical marker of Alzheimer’s disease (AD).
Agustina Birba, Agustina Birba, Eugenia Hesse, Eugenia Hesse, Eugenia Hesse, Lucas Sedeño, Lucas Sedeño, Ezequiel P. Mikulan, Ezequiel P. Mikulan, María del C. García, Juan Ávalos, Federico Adolfi, Federico Adolfi, Agustina Legaz, Tristán A. Bekinschtein, Máximo Zimerman, Mario Parra, Mario Parra, Mario Parra, Mario Parra, Adolfo M. García, Adolfo M. García, Adolfo M. García, Agustín Ibáñez, Agustín Ibáñez, Agustín Ibáñez, Agustín Ibáñez, Agustín Ibáñez   +27 more
doaj   +1 more source

A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating

Nature Communications, 2022
Animals refer to related past experiences when processing sensory inputs. The authors show that a cellular ensemble in the posterior parietal cortex that is activated during past experience mediates an interaction between past and current information to ...
Akinobu Suzuki, Sakurako Kosugi, Emi Murayama, Eri Sasakawa, Noriaki Ohkawa, Ayumu Konno, Hirokazu Hirai, Kaoru Inokuchi   +7 more
doaj   +1 more source

A Computational Model for Spatial Navigation Based on Reference Frames in the Hippocampus, Retrosplenial Cortex, and Posterior Parietal Cortex

Front. Neurorobot., 2017
Behavioral studies for humans, monkeys, and rats have shown that, while traversing an environment, these mammals tend to use different frames of reference and frequently switch between them.
Timo Oess, J. Krichmar, Florian Röhrbein   +2 more
semanticscholar   +1 more source

Exploring if Longitudinal Changes on PET Imaging Can Serve as a Biomarker for Stiff Person Syndrome Spectrum Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify metabolic patterns in the brain and musculoskeletal system of stiff person syndrome spectrum disorders (SPSD) patients over time using PET imaging and evaluate the impact of immune therapy on metabolic activity as a surrogate for treatment response.
Munther M. Queisi, Samantha N. Roman, Mohammad S. Sadaghiani, Lilja B. Solnes, Scott D. Newsome   +4 more
wiley   +1 more source

The parietal association cortex of the rat

Biological Research, 2008
Spatial cognition is a complex higher function in mammals and is involved in a variety of tasks that can be explored in the laboratory. In this review we will discuss the role of the posterior parietal/anteromedial cortex of rodents, also known as the ...
FERNANDO TORREALBA, JOSÉ LUIS VALDÉS
doaj  

The neural substrates of memory suppression: a FMRI exploration of directed forgetting. [PDF]

PLoS ONE, 2012
The directed forgetting paradigm is frequently used to determine the ability to voluntarily suppress information. However, little is known about brain areas associated with information to forget.
Christine Bastin, Dorothée Feyers, Steve Majerus, Evelyne Balteau, Christian Degueldre, André Luxen, Pierre Maquet, Eric Salmon, Fabienne Collette   +8 more
doaj   +1 more source