Results 141 to 150 of about 208,751 (374)

Insight into pericytes in glioblastoma angiogenesis: In vivo tracking by two‐photon microscopy and proteomic profiling

Animal Models and Experimental Medicine, EarlyView.
Based on the inducible pericyte ablation model, we discovered that Pdgfrb+ pericytes regulate glioblastoma (GBM) growth. Using the pericyte lineage tracing model, we revealed their dynamic behavior during GBM angiogenesis. Proteomic analysis combined with pericyte RNA analysis based on human single‐cell data demonstrated cross‐species conserved ...
Qinghong Wang, Chengyan Ma, Xinpei Wang, Mengyuan Li, Xingjiu Yang, Ran Gao   +5 more
wiley   +1 more source

Direction- and distance-dependent interareal connectivity of pyramidal cell subpopulations in the rat frontal cortex

Frontiers in Neural Circuits, 2013
The frontal cortex plays an important role in the initiation and execution of movements via widespread projections to various cortical and subcortical areas.
Yoshifumi eUeta, Yasuharu eHirai, Takeshi eOtsuka, Yasuo eKawaguchi   +3 more
doaj   +1 more source

Representation of remembered stimuli and task information in the monkey dorsolateral prefrontal and posterior parietal cortex.

Journal of Neurophysiology, 2015
Both dorsolateral prefrontal and posterior parietal cortex have been implicated in spatial working memory and representation of task information. Prior experiments training animals to recall the first of a sequence of stimuli and examining the effect of ...
Xue-Lian Qi, Anthony C Elworthy, Bryce C. Lambert, C. Constantinidis   +3 more
semanticscholar   +1 more source

Midlife Steroid‐Binding Globulin Levels and In Vivo Neuroimaging Measures of Tau in Older Men and Women

Annals of Neurology, EarlyView.
Objective In men and women, sex steroid hormones have been associated with increased risk of Alzheimer's disease (AD) dementia. We aimed to investigate the influence of midlife testosterone and sex hormone binding globulin (SHBG) levels on later‐life in vivo markers of β‐amyloid (Aβ) and tau deposition in clinically healthy older men. Methods This time‐
Rachel F. Buckley, Matthew Scott, Emer R. McGrath, Gillian Coughlan, Mabel Seto, Saptaparni Ghosh, Heidi I. L. Jacobs, Claudia L. Satizabal, Emma Thibault, Vasan Ramachandran, Joanne M. Murabito, Reisa A. Sperling, Keith A. Johnson, Ravi Jasuja, Shalender Bhasin, Sudha Seshadri, Alexa S. Beiser   +16 more
wiley   +1 more source

Prediction of Cognitive Decline from White Matter Hyperintensity and Single-Photon Emission Computed Tomography in Alzheimer’s Disease

Frontiers in Neurology, 2017
BackgroundWhile several studies support an association of white matter hyperintensity (WMH) volume and regional cerebral blood flow (rCBF) with cognitive decline in Alzheimer’s disease (AD), no reports have simultaneously considered the effects of both ...
Ken-ichi Tabei, Ken-ichi Tabei, Hirotaka Kida, Tetsuo Hosoya, Masayuki Satoh, Hidekazu Tomimoto, Hidekazu Tomimoto   +6 more
doaj   +1 more source

Functional heterogeneity in posterior parietal cortex across attention and episodic memory retrieval.

Cerebral Cortex, 2014
While attention is critical for event memory, debate has arisen regarding the extent to which posterior parietal cortex (PPC) activation during episodic retrieval reflects engagement of PPC-mediated mechanisms of attention. Here, we directly examined the
J. B. Hutchinson, Melina R. Uncapher, K. Weiner, D. Bressler, M. Silver, A. Preston, A. Wagner   +6 more
semanticscholar   +1 more source

Drawing cartoon faces - a functional imaging study of the cognitive neuroscience of drawing [PDF]

, 2009
We report a functional imaging study of drawing cartoon faces. Normal, untrained participants were scanned while viewing simple black and white cartoon line-drawings of human faces, retaining them for a short memory interval, and then drawing them ...
Gowen, Emma, Miall, R. Chris, Tchalenko, John   +2 more
core   +1 more source

Timing of Changes in Alzheimer's Disease Plasma Biomarkers as Assessed by Amyloid and Tau PET Clocks

Annals of Neurology, EarlyView.
Objective The objective of this study was to evaluate the timing of change of Alzheimer's disease (AD) plasma biomarkers (Aβ42/Aβ40, p‐tau217, p‐tau181, GFAP, and NfL) from six different assay platforms, alongside established AD biomarkers, using amyloid and tau positron emission tomography (PET)‐based AD progression timelines.
Marta Milà‐Alomà, Duygu Tosun, Suzanne E. Schindler, Isabella Hausle, Kellen K. Petersen, Yan Li, Jeffrey L. Dage, Lei Du‐Cuny, Ziad S. Saad, Benjamin Saef, Gallen Triana‐Baltzer, David L. Raunig, Janaky Coomaraswamy, Michael Baratta, Emily A. Meyers, Yulia Mordashova, Carrie E. Rubel, Kyle Ferber, Hartmuth Kolb, Nicholas J. Ashton, Henrik Zetterberg, Erin G. Rosenbaugh, Martin Sabandal, Leslie M. Shaw, Anthony W. Bannon, William Z. Potter, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer's Disease Project Team   +27 more
wiley   +1 more source

The organization of the posterior parietal cortex devoted to upper limb actions: An fMRI study

Human Brain Mapping, 2015
The present fMRI study examined whether upper‐limb action classes differing in their motor goal are encoded by different PPC sectors. Action observation was used as a proxy for action execution.
Stefania Ferri, G. Rizzolatti, G. Orban
semanticscholar   +1 more source

μ‐Opioid Receptor Dynamics in the Parameningeal Tissue During Migraine Attacks

Annals of Neurology, EarlyView.
Objective The possible impact of meningeal μ‐opioid receptor (μOR) binding in migraine remains unknown. This study investigated μOR availability in the cranial parameninges involved in migraine initiation via nociceptor activation. Methods We used positron emission tomography with [11C] carfentanil, and measured μOR availability in meninges and ...
Dajung J. Kim, Manyoel Lim, Thiago D. Nascimento, Frank Porreca, Robert A. Koeppe, Nouchine Hadjikhani, Alexandre F. DaSilva   +6 more
wiley   +1 more source