Results 331 to 340 of about 208,751 (374)

Anatomical circuits for flexible spatial mapping by single neurons in posterior parietal cortex

Ahmed B, Ko HK, Rüsseler M, Smith JET, Krug K.   +4 more
europepmc   +1 more source

Diffusion imaging shows microstructural alterations in untreated, non‐lesional patients already after a first unprovoked seizure

Epilepsia, Volume 66, Issue 3, Page 833-846, March 2025.
Abstract Objective Patients with newly diagnosed epilepsy exhibit brain white matter (WM) abnormalities, but the temporal dynamics of these are unknown. The literature suggests these alterations might be present before diagnosis. This study investigates WM microstructural integrity using diffusion imaging in non‐lesional (NL), interictal epileptiform ...
Marysol Segovia‐Oropeza, Erik Hans Ulrich Rauf, Ev‐Christin Heide, Niels K. Focke   +3 more
wiley   +1 more source

Rare dysfunctional SCN2A variants are associated with malformation of cortical development

Epilepsia, Volume 66, Issue 3, Page 914-928, March 2025.
Abstract Objective SCN2A encodes the voltage‐gated sodium (Na+) channel α subunit NaV1.2, which is important for the generation and forward and back propagation of action potentials in neurons. Genetic variants in SCN2A are associated with a spectrum of neurodevelopmental disorders.
Jérôme Clatot, Christopher H. Thompson, Susan Sotardi, Jinan Jiang, Marina Trivisano, Simona Balestrini, D. Isum Ward, Natalie Ginn, Brunetta Guaragni, Laura Malerba, Angeliki Vakrinou, Mia Sherer, Ingo Helbig, Ala Somarowthu, Sanjay M. Sisodiya, Roy Ben‐Shalom, Renzo Guerrini, Nicola Specchio, Alfred L. George Jr, Ethan M. Goldberg   +19 more
wiley   +1 more source

A new perspective on drug‐resistant epilepsy in children with focal cortical dysplasia type 1: From challenge to favorable outcome

Epilepsia, Volume 66, Issue 3, Page 632-647, March 2025.
Abstract Objective We comprehensively characterized a large pediatric cohort with focal cortical dysplasia (FCD) type 1 to expand the phenotypic spectrum and to identify predictors of postsurgical outcomes. Methods We included pediatric patients with histopathological diagnosis of isolated FCD type 1 and at least 1 year of postsurgical follow‐up.
Barbora Splitkova, Katerina Mackova, Miroslav Koblizek, Zuzana Holubova, Martin Kyncl, Katerina Bukacova, Alice Maulisova, Barbora Straka, Martin Kudr, Matyas Ebel, Alena Jahodova, Anezka Belohlavkova, Gonzalo Alonso Ramos Rivera, Martin Hermanovsky, Petr Liby, Michal Tichy, Josef Zamecnik, Radek Janca, Pavel Krsek   +18 more
wiley   +1 more source

Preferential superficial cortical layer activation during seizure propagation

Epilepsia, Volume 66, Issue 3, Page 929-941, March 2025.
Abstract Objective Focal cortical seizures travel long distances from the onset zone, but the long‐distance propagation pathways are uncertain. In vitro and in vivo imaging techniques have investigated the local spread of seizures but did not elucidate long‐distance spread. Furthermore, classical studies in slices suggested seizure spread locally along
Anastasia Brodovskaya, Shinnosuke Shiono, Chengsan Sun, Edward Perez‐Reyes, Jaideep Kapur   +4 more
wiley   +1 more source

Surgical targeting of lateralized 18F‐fluorodeoxyglucose positron emission tomography hypometabolism relates to long‐term epilepsy surgery outcomes

Epilepsia, EarlyView.
Abstract Objective Surgical resection of the seizure onset zone can be an effective treatment for patients with drug‐resistant focal epilepsy. Clinical, electrophysiological, and imaging data are all gathered prior to surgery to localize the seizure onset zone.
Lucas E. Sainburg, Joseph Hoang, Derek J. Doss, Virginia Berry, Alexandra Roche, Andre H. Lagrange, Todd E. Peterson, Gary T. Smith, Dario J. Englot, Victoria L. Morgan   +9 more
wiley   +1 more source

Frequency‐specific alterations in brain connectivity induced by pulvinar stimulation

Epilepsia, EarlyView.
Abstract Objective Deep brain stimulation (DBS) is emerging as a promising therapy for patients with drug‐resistant epilepsy, particularly those who are either unsuitable for or unresponsive to resective surgery. The potential benefit of DBS in these patients may stem from its ability to reduce excessive brain functional connectivity (FC).
Emma Acerbo, Aude Jegou, Stanislas Lagarde, Francesca Pizzo, Julia Makhalova, Agnès Trébuchon, Christian‐George Bénar, Fabrice Bartolomei, Romain Carron   +8 more
wiley   +1 more source

Prospective neuroimaging and neuropsychological evaluation in adults with newly diagnosed focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Few prospective studies exist on newly diagnosed focal epilepsy (NDFE), a critical period for understanding epilepsy's biology and identifying biomarkers and potential interventions. We report a prospective cohort study in patients with NDFE and age‐, sex‐, and education‐matched healthy controls.
Christophe E. de Bezenac, Nicola Leek, Guleed Adan, Ahmad M. S. Ali, Rajiv Mohanraj, Shubhabrata Biswas, Ronan N. Mcginty, Kieran Murphy, Helen Malone, Gus Baker, Perry Moore, Anthony G. Marson, Simon S. Keller   +12 more
wiley   +1 more source

Patterns of phosphorylated tau accumulation in a spectrum of acquired and developmental brain lesions associated with refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Phosphorylated tau (pTau) has been reported in surgical resections in refractory epilepsy. It is unclear whether this is activity‐driven physiological pTau or signifies the advent of neurodegenerative cascades, relevant to memory decline.
Alicja Mrzyglod, Anya Mebrouk, Joanna Bartkiewicz, Hanaa El Hachami, Maritchka Ryniejska, Jane de Tisi, Roland Coras, Ingmar Blumcke, Fenglai Xiao, Anna Miserocchi, Andrew McEvoy, Matthias Koepp, Joan Liu, Maria Thom   +13 more
wiley   +1 more source