Results 71 to 80 of about 12,493 (244)

Is the Safety of Finasteride Correlated With Its Route of Administration: Topical Versus Oral? A Pharmacovigilance Study With Data From the United States Food and Drug Administration Adverse Event Reporting System

International Journal of Dermatology, Volume 65, Issue 1, Page 108-118, January 2026.
ABSTRACT Background The United States Food and Drug Administration (FDA) approved oral finasteride for androgenetic alopecia. In 2022, approximately 2.6 million U.S. men used it for hair loss and prostate conditions. Post‐finasteride syndrome (PFS), proposed in 2012, involves persistent sexual and neuropsychiatric adverse events (AEs) after cessation ...
Aditya K. Gupta, Mesbah Talukder, Sharon A. Keene, Mary A. Bamimore   +3 more
wiley   +1 more source

Therapeutics for Rheumatoid Arthritis: A Phase 4 Clinical Trial Analysis With a Focus on Disability Outcomes

Journal of Clinical Pharmacy and Therapeutics, Volume 2026, Issue 1, 2026.
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease marked by persistent synovitis, cartilage damage, progressive disability, and a significant decline in quality of life. The advent of biologics and small molecule inhibitors has substantially improved disease management and reduced disability.
Nasser M. Alorfi, Fahad S. Alshehri, Ahmed M. Ashour, Mohammed M. Aldurdunji, Mustfa Faisal Alkhanani, Reem Hasaballah Alhasani, Mohammed S. Alharthi, Nasser M. Aldekhail, Anjali Chauhan   +8 more
wiley   +1 more source

An international initiative to create a collaborative for pharmacovigilance in hospice and palliative care clinical practice [PDF]

, 2012
Background: Medication registration currently requires evidence of safety and efficacy from adequately powered phase 3 studies. Pharmacovigilance (phase 4 studies, postmarketing data, adverse drug reaction reporting) provide data on more widespread and
Abernethy, Amy Pickar, Currow, David Christopher, Doogue, Matthew, Rowett, Debra Sharon, To, Timothy H M   +4 more
core   +1 more source

A Critical Review of the FDA’s Draft Guidance on Artificial Intelligence in Drug and Biological Product Regulation

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Artificial intelligence (AI) has reached a critical juncture in its integration with healthcare and pharmaceutical developments. Regulatory agencies worldwide are developing frameworks to guide the responsible implementation of AI‐driven drug development and approval processes. The United States Food and Drug Administration (FDA) released its inaugural
Sarfaraz K. Niazi, Sohini Basu Roy
wiley   +1 more source

What is the addiction risk associated with tramadol? [PDF]

, 2005
Tramadol (Ultram, generic and with acetaminophen in Ultracet) carries a risk of substance abuse (strength of recommendation [SOR]: B, based on case report surveillance programs).
Mackler, Leslie, McDiarmid, Todd
core  

STD Services Delivery Arrangements in Georgia County Health Departments [PDF]

, 2017
Background: Uniformity, standardization, and evidence-based public health practice are needed to improve the efficiency and quality of services in local health departments (LHDs).
Angie Peden, Bill Livingood, Gulzar H. Shah, Karmen S. Williams   +3 more
core   +2 more sources

Understanding Cardiovascular Events With JAK Inhibitors: Similarities and Differences of the Vascular Effects Between Different JAK Inhibitors on Endothelial Cells Exposed to Inflammatory Cytokines

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Objective A cardiovascular safety issue has been associated with JAK inhibitors (JAKi). This study compares the effects of distinct approved JAKi on endothelial cell (EC) dysfunction and apoptosis during inflammation. Methods Massive inflammation was induced in human vascular ECs by tumor necrosis factor (TNF) with interleukin‐17A (IL‐17A) treated or ...
Aliki Zavoriti, Pierre Miossec
wiley   +1 more source

Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study

Cardiology and Therapy, 2019
Introduction Following approval of dabigatran and other antithrombotics in Japan, few studies have specifically evaluated the clinical characteristics of patients prescribed these antithrombotics for nonvalvular atrial fibrillation (NVAF) in real-world ...
Yukihiro Koretsune, Koichi Kusakawa, Kouji H. Harada, Akio Koizumi, Shinichiro Uchiyama, Hirotsugu Atarashi, Ken Okumura, Masahiro Yasaka, Takeshi Yamashita, Atsushi Taniguchi, Taku Fukaya, Hiroshi Inoue, for J-dabigatran surveillance and JAPAF study investigators   +12 more
doaj   +1 more source

A Guide for Initiating and Managing Chimeric Antigen Receptor T Cell Therapy Clinical Trials in Autoimmune Rheumatic Diseases

ACR Open Rheumatology, Volume 7, Issue 12, December 2025.
Chimeric antigen receptor (CAR) T‐cell therapy, long transformative in oncology, is now rapidly emerging as a frontier in autoimmune rheumatic diseases, particularly systemic lupus erythematosus (SLE), driven by accumulating evidence of deep B‐cell depletion, immune “resetting,” and durable drug‐free remission in early studies, yet its translation into
Roberto Caricchio, Stacie Bell, Sasha Bernatsky, Maria Dall'Era, David Goddard, Kenneth Kalunian, Alfred H. J. Kim, Fotios Koumpouras, Jose Rubio, Amit Saxena, Saira Sheikh, on behalf of the Lupus Clinical Investigators Network   +11 more
wiley   +1 more source

Design and baseline characteristics of the Xarelto Post‐Authorization Safety & Effectiveness Study in Japanese Patients with Atrial Fibrillation (XAPASS)

Journal of Arrhythmia, 2018
Background The phase III Japanese Rivaroxaban Once‐Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation (J‐ROCKET AF) showed that the rivaroxaban group had a lower ...
Satoshi Ogawa, Kazuo Minematsu, Takanori Ikeda, Takanari Kitazono, Jyoji Nakagawara, Susumu Miyamoto, Yuji Murakawa, Yohei Ohashi, Makiko Takeichi, Yutaka Okayama, Satoshi Yamanaka, Lyo Inuyama   +11 more
doaj   +1 more source