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Postmenopausal osteoporosis and alendronate
Maturitas, 2004Osteoporosis is a systemic metabolic disorder associated with a decreased bone mass and resistance. Bisphosphonates suppress bone resorption and bone turnover by a mechanism that depends on their structure. They are characterized by low gastrointestinal absorption. In postmenopausal women, alendronate (ALN) reduces bone resorption markers and increases
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Postmenopausal osteoporosis management
Current Opinion in Obstetrics and Gynecology, 2000Osteoporosis is perhaps the widest-ranging social, physical, and economic impact of estrogen deficiency. Postmenopausal bone loss is the major determinant of osteoporosis. Osteoporotic risk can be determined by measuring bone mineral density using dual X-ray absorptiometry.
M, Gambacciani, M, Ciaponi
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Treatment of Postmenopausal Osteoporosis
JAMA, 2001POSTMENOPAUSAL OSTEOPOROSIS IS a common and serious clinical problem. As both individuals and society have come to recognize the importance of preventing and treating osteoporosis, several new medications have been developed that have been shown to reduce fracture rates in women with osteoporosis.
D, Altkorn, T, Vokes
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Treatment of Postmenopausal Osteoporosis
Drugs, 1979Bone loss can be prevented by standard oestrogen replacement therapy and delayed by the administration of calcium supplements. The most suitable patients to treat are those with a raised urinary hydroxyproline or other evidence of rapid bone loss. Patients aged below 65 years with established osteoporosis, and in whom oestrogens are not contraindicated,
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ESTROGENS AND POSTMENOPAUSAL OSTEOPOROSIS
Clinical Obstetrics and Gynecology, 1976A model for the development of osteoporosis is presented and the tre atment of the condition with estrogens is discussed. It appears that an age-related reduction in circulating estrogens accompanies menopausal bone loss. However this loss is more directly attributable to the lack of parathyroid hormone (PTH) while estrogens play a role in the bony ...
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Calcitriol for Postmenopausal Osteoporosis
Annals of Internal Medicine, 1990Excerpt To the Editor:Gallagher and Riggs (1) recently criticized the report by Ott and Chesnut (2) on calcitriol treatment in postmenopausal osteoporosis.
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Treatment of Postmenopausal Osteoporosis
Annals of Internal Medicine, 1987Excerpt To the editor: In their recent article, Ettinger and colleagues (1) state that 9.0% of untreated women with postmenopausal osteoporosis and 10.5% of women given calcium supplements had mean...
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Pathogenesis of postmenopausal osteoporosis
Baillière's Clinical Rheumatology, 1993Osteoporosis is a disorder of ageing that shares with other disorders of ageing a multifactorial pathogenesis. The important factors for osteoporosis include the diet, life-style and intercurrent factors such as disease. However, it is clear that loss of ovarian function is an important determinant of bone loss, and oestrogen appears to be the key ...
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Treatment of postmenopausal osteoporosis
The Lancet, 2002The aim of treatment of postmenopausal osteoporosis is to reduce the frequency of vertebral and non-vertebral fractures (especially at the hip), which are responsible for morbidity associated with the disease. Results of large placebo controlled trials have shown that alendronate, raloxifene, risedronate, the 1-34 fragment of parathyroid hormone, and ...
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