Results 61 to 70 of about 176,759 (357)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Knowledge, Attitude, and Perception of Postmortem Examination Among Doctors and Nurses in a Tertiary Hospital of Sokoto, Nigeria

Journal of Forensic Science and Medicine, 2016
Postmortem examination is a highly specialized surgical procedure that consists of a thorough examination of a corpse to determine the cause and manner of death and to evaluate any disease or injury that may be present.
A U Kaoje, U Mohammed, A Abdulkarim, M O Raji, U M Ango, B A Magaji   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Expression of specific ionotropic glutamate and GABA-A receptor subunits is decreased in central amygdala of alcoholics

Frontiers in Cellular Neuroscience, 2014
The central nucleus of amygdala (CeA) has a role for mediating fear and anxiety responses. It is also involved in emotional imbalance caused by alcohol abuse and dependence and in regulating relapse to alcohol abuse.
Zhe eJin, Amol K Bhandage, Igor eBazov, Olga eKononenko, Georgy eBakalkin, Esa R Korpi, Bryndis eBirnir   +6 more
doaj   +1 more source

Psychosis in Alzheimer's Disease Is Associated With Increased Excitatory Neuron Vulnerability and Post-transcriptional Mechanisms Altering Synaptic Protein Levels

Frontiers in Neurology, 2022
Alzheimer's disease with psychosis (AD+P) is a heritable phenotypic variant of the disease which is associated with more rapid cognitive deterioration compared to Alzheimer's disease without psychosis (AD–P).
Michael R. DeChellis-Marks, Yue Wei, Ying Ding, Cody M. Wolfe, Joshua M. Krivinko, Matthew L. MacDonald, Oscar L. Lopez, Oscar L. Lopez, Robert A. Sweet, Robert A. Sweet, Julia Kofler   +10 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Stereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia

Frontiers in Neuroanatomy, 2018
It has long been known that auditory processing is disrupted in schizophrenia. More recently, postmortem studies have provided direct evidence that morphological alterations to neurons in auditory cortex are implicated in the pathophysiology of this ...
Emily M. Parker, Robert A. Sweet, Robert A. Sweet, Robert A. Sweet   +3 more
doaj   +1 more source

Modeling Postmortem Ethanol Production/Insights into the Origin of Higher Alcohols

Molecules, 2022
The forensic toxicologist is challenged to provide scientific evidence to distinguish the source of ethanol (antemortem ingestion or microbial production) determined in the postmortem blood and to properly interpret the relevant blood alcohol ...
Vassiliki A. Boumba
doaj   +1 more source

Advantages of Postmortem Angiography in the Daily Routine of Legal Medicine

, 2016
If applied by an experienced team, postmortem CT angiography (PMCTA) has a number of advantages, most of which have been explained in detail in earlier sections of this book.
Silke Grabherr, Grimm, Jochen M., Grabherr, Silke, Jochen M. Grimm   +3 more
core   +1 more source

Robust postmortem survival of murine vestibular and cochlear stem cells [PDF]

, 2007
Potential treatment strategies of neurodegenerative and other diseases with stem cells derived from nonembryonic tissues are much less subjected to ethical criticism than embryonic stem cell-based approaches.
Teo, Dawn, Oshima, Kazuo, Senn, Pascal, Grimm, Christian, Heller, Stefan   +4 more
core   +1 more source