Results 31 to 40 of about 457 (209)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Superior Canal Dehiscence: A Comparative Postmortem Multislice Computed Tomography Study

OTO Open, 2018
Objective Superior canal dehiscence is defined by missing bony coverage of the superior canal against the middle cranial fossa. The gold standard in diagnosis is high-resolution computed tomography (CT). A false-positive CT scan, identifying a dehiscence
Philipp Mittmann MD, Arne Ernst MD, Rainer Seidl MD, Anna-Felicitas Skulj MD, Sven Mutze MD, Marc Windgassen MD, Claas Buschmann MD   +6 more
doaj   +1 more source

Post-mortem computed tomography (PMCT) and PMCT-angiography after transvascular cardiac intervention

Archives of Forensic Medicine and Criminology, 2014
Background and Purpose: During the last years, Post Mortem Computed Tomography (PMCT) has become an integral part of the autopsy. PMCT-angiography may augment PMCT.
Beatrice Vogel, Axel Heinemann, Axel Gehl, Iwao Hasegawa, Wilhelm-Wolfgan Höpker, Chanasom Poodendaen, Antonios Tzikas, Helmut Gulbins, Hermann Reichenspurner, Klaus Püschel, Hermann Vogel   +10 more
doaj   +1 more source

Identification of aortic injury site using postmortem non–contrast computed tomography in road traffic accident

Radiology Case Reports, 2021
In high-speed motor vehicle accidents, it is necessary to investigate the manner of death. Postmortem computed tomography (PMCT) provides important information on the mechanism of death, but identification of the aortic injury is still challenging on non–
Keiichi Horie, MD, Yoko Ihama, MD, PhD, Shinjiro Aso, MD, Hikaru Kuninaka, MD, Hidekazu Mochizuki, RT, Tsuneo Yamashiro, MD, PhD, Shingo Kato, MD, PhD, Daisuke Utsunomiya, MD, PhD   +7 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Imaging Characteristics of Frozen Corpses: An Analysis Based on Postmortem Computed Tomography

Journal of Forensic Science and Medicine
Background: As traditional autopsy rates decline, the importance of forensic imaging, particularly postmortem computed tomography (PMCT), grows for non-invasive cause of death determination and evidence collection in legal investigations, with unique ...
Sunao Li, Wenju Jin, Jiahui He, Jun He, Mingjie Qiu, Wenjing Gao, Long Fu, Haibin Shen, Zhiyuan Xia, Xilian Ding   +9 more
doaj   +1 more source

Examination of postmortem changes in the lungs, trachea, and bronchi in a rat model imaged with small-animal computed tomography

Fujita Medical Journal, 2023
Objectives: As less autopsies are performed, the need for postmortem computed tomography (PMCT) as an alternative is increasing. It is important to know how postmortem changes over time are reflected on CT, in order to improve the diagnostic capability ...
Takahiro Matsuyama, Seiichiro Ota, Yoshitaka Inui, Naoko Fujii, Tetsuya Tsukamoto, Ichiro Isobe, Katsumi Tsujioka, Shizuko Nagao, Ryosuke Tanabe, Hiroshi Toyama   +9 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Heart wall is thicker on postmortem computed tomography than on antemortem [corrected] computed tomography: the first longitudinal study.

PLoS ONE, 2013
ObjectiveTo evaluate the postmortem changes of the heart wall on postmortem (PM) computed tomography (CT) in comparison with those on ante mortem CT (AMCT), and in comparison with the pathological findings, obtained in the same patients.Materials and ...
Hidemi Okuma, Wataru Gonoi, Masanori Ishida, Yukako Shintani, Yutaka Takazawa, Masashi Fukayama, Kuni Ohtomo   +6 more
doaj   +1 more source