Results 251 to 260 of about 65,285 (343)

TRIM38 Suppresses Breast Cancer Progression via Modulating SQSTM1 Ubiquitination and Autophagic Flux

Advanced Science, EarlyView.
TRIM38, an E3 ubiquitin ligase, suppresses breast cancer progression by inhibiting proliferation, migration, and invasion. Downregulated in breast tumor, its loss correlates with poor prognosis. Mechanistically, TRIM38 mediates K63‐linked ubiquitination of SQSTM1/p62 at K420, disrupting SQSTM1‐LC3 interaction and blocking autophagic flux.
Shan Jiang, Lijuan Wang, Dianwen Han, Peng Su, Bing Chen, Wenjing Zhao, Tong Chen, Ning Zhang, Xiaolong Wang, Yiran Liang, Yaming Li, Chen Li, Xi Chen, Dan Luo, Qifeng Yang   +14 more
wiley   +1 more source

Seasonal mouse cadaver microbial study: rupture time and postmortem interval estimation model construction. [PDF]

PeerJ
Zhao X, Yang F, Yang F, Nie H, Hu S, Gui P, Guo Y, Zhang C.   +7 more
europepmc   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

Advanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo, Seong‐Gook Kang, Kunlun Huang, Tao Tong   +3 more
wiley   +1 more source

Estimating postmortem interval based on oral microbial community succession in rat cadavers. [PDF]

Heliyon
Wang X, Le C, Jin X, Feng Y, Chen L, Huang X, Tian S, Wang Q, Ji J, Liu Y, Zhang H, Huang J, Ren Z.   +12 more
europepmc   +1 more source

Determination of the Late Postmortem Interval by Observing the Electrical Conductivity in Skeletal Muscles of Rats

Shazia Umer, Madiha Shujat, Noreen Kashif, Muhammad Hassaan, Umer Hussain, Durdana Zafar   +5 more
openalex   +2 more sources

MDP25‐VDAC3 Complex Orchestrates Actin Remodeling and Mitochondrial Dynamics to Modulate Innate Immunity in Arabidopsis

Advanced Science, EarlyView.
This study reveals that actin remodeling regulates mitochondrial elongation as a defense strategy in plants. Flagellin perception induces fusion‐dependent elongation, supported by cortical actin bundles, to repair damage and boost ATP and ROS production.
Junxiu Hou, Pengfei Lu, Xuan Cui, Liangfeng Luo, Qing Pan, Jiejie Li   +5 more
wiley   +1 more source

Application of Metabolomics and Machine Learning for the Prediction of Postmortem Interval.

Cureus
Aljeaid R.
europepmc   +1 more source

Development of Mathematical Models Using circRNA Combinations (<i>circTulp4</i>, <i>circSlc8a1</i>, and <i>circStrn3</i>) in Mouse Brain Tissue for Postmortem Interval Estimation. [PDF]

Int J Mol Sci
Song B, Fu J, Qian J, He T, Cheng J, Chiampanichayakul S, Anuchapreeda S, Fu J.   +7 more
europepmc   +1 more source

Initial Distance‐Dependent Mean Force Drives Synaptic Vesicle Motion Toward Fusion Sites in Stimulated Hippocampal Neurons

Advanced Science, EarlyView.
Synaptic vesicle (SV) motion and exocytosis dynamics in the presynaptic terminals of live neurons are intimately linked to synaptic transmission during neuronal activity. In this work, it is revealed that, during electrical stimulation, SVs located farther from their fusion sites exhibit greater straightness and experience larger mean forces directed ...
Gyunam Park, Ji‐Hyun Kim, Hunki Lee, Chungwon Park, Sidong Chen, Luke Bates, Jaeyoung Sung, Hyokeun Park   +7 more
wiley   +1 more source