Results 191 to 200 of about 24,629 (250)

Do Brain Extracellular Fluid Concentrations Predict PET‐Inferred Receptor Occupancy in Human CNS? A Mechanistic Model‐Based Analysis of Dopamine D2 Receptor Ligands

Clinical Pharmacology &Therapeutics, EarlyView.
A mechanistic CNS PBPK model framework was applied to eight antipsychotic D2 receptor ligands, comparing brain extracellular fluid (brainECF) and brain cell membrane (brainM) as biophase for predicting human receptor occupancy compared against PET neuroimaging data. BrainM concentrations showed improved agreement with PET‐derived receptor occupancy for
Divakar Budda, J.G. Coen van Hasselt, Elizabeth C.M. de Lange   +2 more
wiley   +1 more source

Tau Pathology in Alzheimer's Disease Uniquely Affects Sulcal Depths. [PDF]

Ann Neurol
Maboudian SA, Fonseca CS, Martersteck AC, Chao Y, Chen Y, Ushizima D, Tosun D, Grinberg LT, Weiner KS, Jagust WJ, Alzheimer's Disease Neuroimaging Initiative.   +10 more
europepmc   +1 more source

Enhanced Ionic Conductivity and Moisture Stability of Zr‐Based Halide Solid Electrolytes via Ta5+ Doping for All‐Solid‐State Batteries

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
The high‐valence Ta5+‐substituted LZC (LZT0.3C) demonstrates high ionic conductivity, excellent compressibility, and impressive moisture stability, contributing to the long‐term cycling durability of ASSLBs. Recently developed halide solid‐state electrolytes (SSEs) have become promising alternatives for the next generation inorganic SSEs, primarily due
Jin Hu, Yuhan Ma, Yihao Cheng, Chunsheng Shi, Biao Chen, Liying Ma, Jianli Kang, Fang He, Naiqin Zhao, Chunnian He   +9 more
wiley   +1 more source

Case report: intracranial fungal granuloma in a dromedary (Camelus dromedarius). [PDF]

BMC Vet Res
Schmidt ML, Sickinger M, Rickerts V, McCormick-Smith I, Köhler K.   +4 more
europepmc   +1 more source

Next‐Generation Carbon‐Based Anodes for Alkali Metal‐Ion Batteries: Recent Progress on Biphenylene and Emerging Materials

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
Recent advances in carbon‐based anodes for alkali metal‐ion batteries are critically reviewed, with emphasis on biphenylene and other emerging carbon allotropes. Biphenylene exhibits exceptional theoretical electrochemical properties beyond conventional graphite, highlighting its strong potential as a next‐generation anode material once scalable ...
Adewale Hammed Pasanaje, Nirpendra Singh
wiley   +1 more source

One Health Investigation into Fatal Encephalitis Caused by Pigeon Paramyxovirus Type 1, France. [PDF]

Emerg Infect Dis
Veyrenche N, Boluda S, Pérot P, Malissin I, Leruez-Ville M, Jamet A, Ferroni A, Regnault B, Salmona M, Feghoul L, Robert-Capraro L, Leroux A, Grasland B, Niqueux E, Briand FX, Plu I, Seilhean D, Megarbane B, Fourgeaud J, Dheilly NM.   +19 more
europepmc   +1 more source

Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty

ESC Heart Failure, Volume 12, Issue 2, Page 955-967, April 2025.
Abstract Wild‐type transthyretin amyloid cardiomyopathy (ATTRwt‐CM) is a progressive and infiltrative cardiac disorder that may cause fatal consequences if left untreated. The estimated survival time from diagnosis is approximately 3–6 years. Because of the non‐specificity of initial symptom manifestation and insufficient awareness among treating ...
Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita   +9 more
wiley   +1 more source

Acute susceptibility changes of deep gray matter nuclei to gadobutrol: a prospective longitudinal study using quantitative susceptibility mapping. [PDF]

Quant Imaging Med Surg
Yang M, Zhang Q, Liang X, Lv P, Tang R, Lin Z, Tian C, Zhang X, Zhang B.   +8 more
europepmc   +1 more source

Correlation between in vivo ¹⁸F-flortaucipir PET and whole-brain postmortem histological tau signals in Alzheimer's disease. [PDF]

Alzheimers Dement
Chao Y, Chen Y, Chadwick TA, Harrison TM, Iaccarino L, Heinsen H, Ushizima D, Tosun D, Jagust WJ, Grinberg LT.   +9 more
europepmc   +1 more source

Real‐world characteristics and treatment of cardiac transthyretin amyloidosis: A multicentre, observational study

ESC Heart Failure, Volume 12, Issue 2, Page 1203-1216, April 2025.
The 366 patients diagnosed with transthyretin amyloidosis cardiomyopathy (ATTR‐CM) were analyzed regarding their clinical characteristics in the first year after approval of tafamidis 61 mg for ATTR‐CM in Germany. Nearly two‐thirds of the patients were in an advanced disease stage and 64% met the key criteria of the “Transthyretin Amyloidosis ...
Richard J. Nies, Svenja Ney, Ingrid Kindermann, Yvonne Bewarder, Angela Zimmer, Fabian Knebel, Katrin Hahn, Sebastian Spethmann, Peter Luedike, Lars Michel, Tienush Rassaf, Maria Papathanasiou, Stefan Störk, Vladimir Cejka, Amin Polzin, Fabian Voss, Malte Kelm, Bernhard Unsöld, Christine Meindl, Michael Paulus, Ali Yilmaz, Bishwas Chamling, Caroline Morbach, Roman Pfister   +23 more
wiley   +1 more source