Results 321 to 330 of about 2,801,427 (391)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Effect of Intraoperative Active Warming Initiated at Anesthesia Induction on Core Temperature, Postoperative Pain and Agitation in Laparoscopic Cholecystectomy: A Randomized Controlled Trial. [PDF]

Medicina (Kaunas)
Dedeoğlu A, Acil F, Andıç O, Özkılıç M.   +3 more
europepmc   +1 more source

Microglial Membranes Wrapped Ultrasmall Medium‐Entropy Ru Single‐Atom Nanozyme: Enhanced Catalysis for Accelerating Inflammation/Redox Microenvironment Regulation in Intracerebral Hemorrhage

Advanced Science, EarlyView.
PtRhIr/Ru SAN@M nanozymes cross the blood–brain barrier and selectively accumulate in hemorrhagic brain regions. By mimicking multiple enzyme activities, they attenuate oxidative stress, modulate microglial polarization toward an anti‐inflammatory phenotype, inhibit ferroptosis, and promote neuronal repair.
Jiebo Li, Penghui Wei, Yuanbo Pan, Hongjia Zheng, Jiajun Hu, Qianxi Chen, Zhongyuan Shen, Yongrui Hu, Jiajun Wu, Fuxin Lin, Fuxiang Chen, Chenyu Ding, Wenhua Fang, Yuanxiang Lin, Dezhi Kang, Yuxiang Gu, Yang Zhu, Dengliang Wang   +17 more
wiley   +1 more source

Effects of Ultrasound-Guided Oblique Subcostal Transversus Abdominis Block Combined With Patient-Controlled Intravenous Analgesia on Analgesia and Early Recovery After Open Hepatectomy: A Randomized Controlled Clinical Trial. [PDF]

Clin J Pain
Wang C, Xu W, Li Y, Sun Y, Chen W, Yang W, An K.   +6 more
europepmc   +1 more source

Continuous wound infiltration versus placebo following elective minimally invasive colorectal surgery (CIMICS): study protocol for a randomised controlled trial. [PDF]

PLoS One
Glazemakers S, Ketelaers SHJ, Scholten HJ, Schipper RJ, Meesters MI, Burger JWA, Bloemen JG.   +6 more
europepmc   +1 more source

Postoperative prognostic factors for inability to walk at 6 weeks after fragility hip fracture surgery: A retrospective cohort study. [PDF]

Biomed Rep
Jongutchariya T, Saengsuwan J, Loomcharoen P.   +2 more
europepmc   +1 more source