Results 231 to 240 of about 498,713 (301)

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Ultrasound-Guided Transversalis Fascia Plane Block Versus Transversus Abdominis Plane Block for Postoperative Analgesia After Repeat Cesarean Delivery: A Prospective Observational Study. [PDF]

Healthcare (Basel)
Ötügen TE, Akyol F, Karataş T, Ataş G, Taş HG, Kuyrukluyıldız U.   +5 more
europepmc   +1 more source

Population Pharmacokinetics and Transfer of Gabapentin When Used as a Pain Adjunct for Cesarean Deliveries

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 551-560, March 2025.
ABSTRACT Enhanced Recovery After Surgery (ERAS) protocols for cesarean deliveries (CDs) utilize multimodal pain management strategies that often include gabapentin. While gabapentin is excreted in breast milk, its pharmacokinetics in immediately postpartum lactating women are not known. This observational pharmacokinetic study (NCT05099484) enrolled 21
Rebecca Silvola, Aislinn O'Kane, Michael Heathman, Hannah Marotta, Hayley Trussel, Bobbie Ray, Shelley Dowden, Andrea R. Masters, David M. Haas, Sara K. Quinney   +9 more
wiley   +1 more source

Comparative Evaluation of Caudal Dexmedetomidine vs. Tramadol As Adjuvants to Bupivacaine for Intraoperative Hemodynamic Stability and Postoperative Analgesia in Pediatric Infraumbilical Surgeries. [PDF]

Cureus
Abbas N, Bilal A, Tariq H, Shahzadi H, Shahid M, Riaz A.   +5 more
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Efficacy of Dexmedetomidine Added to Ropivacaine for Four-Quadrant Transversus Abdominis Plane Blocks on Hemodynamic Response and Postoperative Analgesia in Laparoscopic Cholecystectomy. [PDF]

Cureus
Kore MS, Shrivastava P, Kumar M, Xess PA, Lakra A.   +4 more
europepmc   +1 more source

Advances in research on layered double hydroxides for biomedical applications

Smart Molecules, EarlyView.
Layered double hydroxides (LDHs) are pH‐responsive nanomaterials with broad biomedical applications. This review summarizes LDH synthesis methods and compares their advantages. It highlights LDHs' progress in cancer therapy, including chemo‐photothermal, chemo‐immunotherapy, and photodynamic‐immunotherapy combinations and their potential in bone repair.
Xinhui Yang, Zhiping Zhang, Zhao Wang, Hao Zhang, Yen Leng Pak, Yingying Jing, Yurong Guo, Fang Li, Xiao Wang, Quanxiang Han, Lei Yu, Xuejiao Li, Xing Gao, Jibin Song   +13 more
wiley   +1 more source

Efficacy and safety of Oliceridine versus Sufentanil in postoperative analgesia for burn skin grafting: a machine learning and SHAP-based cohort study. [PDF]

Front Med (Lausanne)
Tian Y, Zhang Y, Feng D, Wang H, Ma Z.
europepmc   +1 more source

Preoperative caudal blocks associated with decreased cumulative opioid requirements compared to postoperative caudal blocks in pediatric urologic surgery

UroPrecision, EarlyView.
Abstract Background Caudal blocks (CB) are a cornerstone of pediatric urologic surgery, providing effective analgesia while mitigating potential neurotoxicity associated with general anesthesia and opioids. However, the optimal timing of CB—preoperative versus postoperative—remains controversial.
Jordan L. Mendelson, William Brenseke, Diego Alvarez Vega, William Nguyen, Mohammed Shium, Saige Gitlin, Ronnie G. Fine, Steven C. Friedman, Mark Horowitz, Walter I. Weiss, Raghu Idupuganti, Jordan S. Gitlin   +11 more
wiley   +1 more source

Erector spinae plane block vs. paravertebral block for postoperative analgesia in breast surgery: a meta-analysis of randomized trials. [PDF]

Braz J Anesthesiol
Dost B, Karapinar YE, Beldagli M, Turunc E, Kaya C, De Cassai A.   +5 more
europepmc   +1 more source