Results 51 to 60 of about 1,138,899 (331)

Application of Multiple Omics to Understand Postoperative Delirium Pathophysiology in Humans

Gerontology, 2023
Delirium, an acute change in cognition, is common, morbid, and costly, particularly among hospitalized older adults. Despite growing knowledge of its epidemiology, far less is known about delirium pathophysiology.
S. Vasunilashorn, S. Dillon, E. Marcantonio, T. Libermann   +3 more
semanticscholar   +1 more source

General anesthesia does not have persistent effects on attention in rodents [PDF]

, 2019
Background: Studies in animals have shown that general anesthesia can cause persistent spatial memory impairment, but the influence of anesthetics on other cognitive functions is unclear.
Amanda G. Nelson, George A. Mashour, George A. Mashour, Katherine A. LaTendresse, Margaret Phyle, Michael S. Avidan, Romi E. Ajluni, Viviane S. Hambrecht-Wiedbusch, Viviane S. Hambrecht-Wiedbusch   +8 more
core   +2 more sources

Postoperative Delirium after Dexmedetomidine versus Propofol Sedation in Healthy Older Adults Undergoing Orthopedic Lower Limb Surgery with Spinal Anesthesia: A Randomized Controlled Trial

Anesthesiology, 2022
Background: Delirium is a critical postoperative complication in older patients. Based on the hypothesis that intraoperative dexmedetomidine sedation would lower postoperative delirium than propofol sedation would, the authors compared the incidence of ...
Hyun-Jung Shin, Sun Woo Nam, H. Kim, Su-Hoon Yim, Sunghee Han, Jung-Won Hwang, S. Do, H. Na   +7 more
semanticscholar   +1 more source

Raised preoperative monocyte chemoattractant protein-1 as the independent predictor of delirium after cardiac surgery. A prospective cohort study

European Psychiatry, 2021
Introduction Delirium is a frequent and serious complication of cardiac surgery. However, the knowledge regarding pathogenesis of postoperative delirium is limited.
J. Kaźmierski, P. Miler, A. Pawlak, H. Jerczyńska, E. Frankowska, J. Woźniak, K. Woźniak, A. Brzezińska, M. Wilczyński   +8 more
doaj   +1 more source

Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium [PDF]

, 2014
Objective: The neuropathogenesis of postoperative delirium remains unknown. Low cerebrospinal fluid (CSF) β-amyloid protein (Aβ) and high CSF Tau levels are associated with Alzheimer's disease.
Burke, Dennis W, Dong, Yuanlin, Escobar, Diana, Marcantonio, Edward R, Sunder, Neelakantan, Swain, Celeste A, Ward, Sarah A P, Xie, Zhongcong, Zhang, Yiying, Zheng, Hui   +9 more
core   +1 more source

The Association of Preoperative Frailty and Postoperative Delirium: A Meta-analysis

Anesthesia and Analgesia, 2021
BACKGROUND: Both frailty and postoperative delirium (POD) are common in elective surgical patients 65 years of age and older. However, the association between preoperative frailty and POD remains difficult to characterize owing to the large number of ...
Thomas J. Gracie, Christine Caufield-Noll, Nae-Yuh Wang, F. Sieber   +3 more
semanticscholar   +1 more source

Cerebrovascular Reserve Capacity as a Predictor of Postoperative Delirium: A Pilot Study

Frontiers in Surgery, 2021
Introduction: Postoperative delirium is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). Compromised regulation of the cerebral circulation may be a predisposing factor for delirium.
Moa Bydén, Anna Segernäs, Hans Thulesius, Hans Thulesius, Farkas Vanky, Eva Ahlgren, Johan Skoog, Helene Zachrisson   +7 more
doaj   +1 more source

Psychometric Properties of the Family Caregiver Delirium Knowledge Questionnaire [PDF]

, 2015
A valid, reliable measure of family caregivers’ knowledge about delirium was not located in the literature; such an instrument is essential to assess learning needs and outcomes of education provided. The purpose of the current study was to (a) develop a
Arbuckle, Cohen, Debra Oswald, Gagnon, Greaves, Greer, Jennifer Sjostedt Avery, Kline, Lesley Boaz, Margaret J. Bull, Mindrila, Nunnally, Polit, Thompson, Ullman   +14 more
core   +2 more sources

Incidence and risk factors of postoperative delirium in elderly surgical patients 2023

Scientific Reports
Postoperative delirium has the potential to impact individuals of all age groups, with a significant emphasis on the elderly population. Its presence leads to an increase in surgical morbidity and mortality rates, as well as a notable prolongation of ...
Efrem Fenta, Diriba Teshome, Simegnew Kibret, Metages Hunie, Abebe Tiruneh, Amsalu Belete, A. Molla, Belayneh Dessie, Kumlachew Geta   +8 more
semanticscholar   +1 more source

Higher intraoperative mean arterial blood pressure does not reduce postoperative delirium in elderly patients following gastrointestinal surgery: A prospective randomized controlled trial.

PLoS ONE, 2022
BackgroundThis study aimed to describe the relationship between the different levels of intraoperative mean arterial blood pressure (MAP) and postoperative delirium in elderly patients undergoing gastrointestinal laparoscopic surgery.Materials and ...
Yanke Zhang, Ying Zhang, Zhou Zhou, Xiaoqiao Sang, Miaomiao Qin, Guangrong Dai, Zhibin Zhao, Fang Yan, Xiaobao Zhang   +8 more
doaj   +1 more source