Results 111 to 120 of about 1,798,300 (303)

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu   +5 more
wiley   +1 more source

Effects of Lidocaine on Reducing the Need for Anesthetic Drugs during Ophthalmologic Surgeries

open access: yesمجله دانشکده پزشکی اصفهان, 2013
Background: The most common postoperative complications are pain, vomiting, and nausea. They may in turn lead to other complications such as wound damage. On the other hand, the use of opioid analgesics has unwanted effects on patients.
Hassan Ali Soltani   +2 more
doaj  

The effects of indomethacin, diclofenac, and acetaminophen suppository on pain and opioids consumption after cesarean section [PDF]

open access: yes
Background: Cesarean section is one of the common surgeries of women. Acute post-operative pain is one of the recognized post-operative complications.
Masood Entezariasl   +7 more
core   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto   +7 more
wiley   +1 more source

Laparoscopic Versus Open Surgery for Diverticular Disease: A Structured Review Across Clinical Settings and Operative Strategies

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Laparoscopic surgery is increasingly used to treat colonic diverticulitis; however, its role in emergency, perforated, high‐risk, and procedure‐specific settings remains uncertain. This structured narrative review evaluated and synthesized comparative evidence by clinical setting, operative strategy, and patient risk profile to provide a ...
Marie Hanaoka   +4 more
wiley   +1 more source

Minimally Invasive Versus Open Total and Distal Gastrectomy After Chemotherapy for Gastric Cancer: A Nationwide Observational Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This nationwide observational study used data from the National Clinical Database. Patients who underwent total or distal gastrectomy for gastric cancer after chemotherapy between January 2014 and December 2022 were included. Minimally invasive surgery was associated with lower incidences of overall postoperative complications of Clavien–Dindo grade ...
Nobuaki Hoshino   +8 more
wiley   +1 more source

Postoperative Pain and Opioid Use in Urogynecology Patients

open access: yesAnesthesia Research
Opioid use disorder remains a leading national cause of mortality. Physician opioid prescribing contributes to this crisis. In urogynecology, most of these prescriptions are aimed at addressing postoperative pain.
Laura DiVirgilio   +2 more
doaj   +1 more source

Small Intestinal Bacterial Overgrowth Following Gastrointestinal Cancer Surgery: Current Evidence and Future Perspectives

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
ABSTRACT Small intestinal bacterial overgrowth (SIBO) has recently gained increasing attention as a potential cause of postoperative gastrointestinal symptoms following gastrointestinal cancer surgery. Surgical procedures can disrupt normal gastrointestinal physiology through anatomical reconstruction, impaired motility, reduced gastric acid secretion,
Toru Aoyama   +2 more
wiley   +1 more source

Barbed Sutures Are Associated With a Lower Incidence of Incisional Hernia Compared With Continuous Non‐Barbed Monofilament Sutures After Minimally Invasive Gastroenterological Surgery

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
Incisional hernia remains a common complication after minimally invasive gastroenterological surgery despite small extraction incisions. In this propensity score‐weighted analysis, barbed sutures significantly reduced the incidence of incisional hernia compared with conventional slowly absorbable monofilament sutures without increasing postoperative ...
Shusaku Honma   +8 more
wiley   +1 more source

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