Results 81 to 90 of about 1,798,300 (303)

The Effect of Ketamine on Posttonsillectomy Pain in Children: A Clinical Trial [PDF]

open access: yes
Introduction: Tonsillectomy is one of the most common surgical operations and has such complications as pain, hemorrhage and laryngospasm. Pain management is of vital importance in order to reduce the suffering and restlessness in children having ...
محمدی, محمدعلی   +3 more
core  

Macrophage Dab1 Links Early Hypoxia to Adaptive Angiogenesis to Drive Peripheral Nerve Repair

open access: yesAdvanced Science, EarlyView.
Schematic diagram illustrating the Dab1‐linked hypoxia signaling pathway that accelerates angiogenesis and consequent nerve regeneration. Following PNI, a hypoxic microenvironment develops. Hypoxia induces macrophage Dab1 phosphorylation, resulting in NHE‐1 upregulation, HIF‐1α stabilization, and VEGF‐A expression. This cascade promotes angiogenesis in
Xiongyao Zhou   +14 more
wiley   +1 more source

A Mouse Model of Postoperative Pain

open access: yesBio-Protocol, 2019
Postoperative pain is highly debilitating and hinders recovery. Opioids are the main pain medication used for acute postoperative pain. Given the devastating opioid addiction and overdose epidemic across the US, non-opioid pain therapeutics are ...
Ashley Cowie, Cheryl Stucky
doaj   +1 more source

The effect of Lidocaine on post-tonsillectomy pain In Children: A Triple-Blind Clinical Trial [PDF]

open access: yes
Introduction: Tonsillectomy is one of the most common surgical operations in children and has complications such as pain, hemorrhage, laryngospasm, postoperative nausea and vomiting.
محمدی, محمدعلی   +4 more
core  

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

open access: yesAdvanced Science, EarlyView.
An acid‐responsive core‐shell microneedle system normalizes the degenerative annulus fibrosus microenvironment by consuming pathological H+, generating O2, and providing NIR‐amplified redox buffering. Mechanistically, it epigenetically suppresses ferroptosis via DNMT3A‐dependent methylation of the ATF3 promoter, relieving ATF3‐mediated repression of ...
Lu Tan   +7 more
wiley   +1 more source

Review of the Current Situation of Postoperative Pain and Causes of Inadequate Pain Management in Africa

open access: yesJournal of Pain Research, 2023
Lejun Gao,1,* Huaixin Mu,2,* Yun Lin,1 Qingping Wen,1,3 Peng Gao1 1Department of Anesthesiology, First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 2Emergency Department, Shenyang Children’s Hospital ...
Gao L, Mu H, Lin Y, Wen Q, Gao P
doaj  

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

open access: yesAdvanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng   +8 more
wiley   +1 more source

Preemptive Effect of Oral Pregabalin on Post-Operative Pain Control in Lower Limb Fractures [PDF]

open access: yes
Background & Objectives: dolnortnccnU postoperative pain can cause many adverse effects such as tachycardia, hypertension, myocardial ischemia, decreased alveolar ventilation and poor wound healing.
اخوان اکبری, قدرت   +3 more
core  

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Zinc transporter SLC39A14 sustains intracellular Zn2+ levels to activate SIRT3‑dependent ANXA2 deacetylation at K302. This modification weakens ANXA2‑mTOR binding and releases autophagic‑flux suppression in nucleus pulposus cells. Dysregulated Zn2+ homeostasis disrupts this axis to drive intervertebral disc degeneration.
Yuxin Jin   +23 more
wiley   +1 more source

Prediction of Acute Postoperative Pain from Assessment of Pain Associated With Venous Cannulation

open access: yes, 2019
Background: It has previously been reported that venous cannulation-induced pain (VCP) can be used to predict acute postoperative pain after laparoscopic cholecystectomy.
Persson, Anna K.M.,   +2 more
core   +2 more sources

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