Results 181 to 190 of about 6,738,408 (363)

A Sirtuin‐1‐Targeted Gene‐Activating Tetrahedral DNA Attenuates Bladder Fibrosis by Restoring Mitophagy in Fibroblasts via the SIRT1‐FOXO3‐BNIP3 Axis

Advanced Science, EarlyView.
The SIRT1‐targeted saRNA‐delivering tetrahedral DNA (TSA) treatment effectively upregulates SIRT1 expression, which subsequently promotes FOXO3A deacetylation. This deacetylation event relieves FOXO3A's transcriptional repression on the BNIP3 gene, thereby initiating PINK1‐PARKIN‐dependent mitophagy.
Wei Wang, Ran Yan, Lede Lin, Lei Xiang, Xiaozhi Xia, Liao Peng, Xiaoshuai Gao, Jiawei Chen, Yang Xiong, Liang Zhou, Yunfeng Lin   +10 more
wiley   +1 more source

Incidence of urehtrocutaneous fistula formation during the first three postoperative months period of hypospadias reconstruction surgeries

, 2023
Muhammad Abdullah Rahman Shwani Shwani, Halgurd Azad Abdullah, Lawand Sardar Abdulhamid Miran   +2 more
openalex   +2 more sources

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Nursing care of a giant acoustic neuroma patient complicated with tonsillar herniation in the postoperative period: A CARE-compliant case report. [PDF]

Medicine (Baltimore)
Chen Y, Hou G.
europepmc   +1 more source

Measurement of serum parathyroid hormone during the early postoperative period as a predictor of clinical hypocalcaemia

, 2017
О. П. Нечай, О. А. Товкай, С. М. Черенько   +2 more
openalex   +2 more sources

Impact on Quality of Life of a Telemedicine System Supporting Head and Neck Cancer Patients: A Controlled Trial During the Postoperative Period at Home [PDF]

, 2007
Jaap L. van den Brink, Peter W. Moorman, Maarten F. de Boer, Wim C.J. Hop, J.F.A. Pruyn, C.D.A. Verwoerd, Jan H. van Bemmel   +6 more
openalex   +1 more source

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Recovery pattern in the early postoperative period after arthroscopic rotator cuff repair: a systematic review. [PDF]

EFORT Open Rev
Choi BC, Kim DH, Cho CH.
europepmc   +1 more source

Factors influencing postoperative hospitalization period after thoracoscopic surgery for acute empyema

, 2018
Eiji Miyahara, Yukari Kawasaki, A. Kimura, Tsuneo Okumichi   +3 more
openalex   +2 more sources

BHLHE40 Orchestrates Effector Tissue‐Resident Memory CD8+ T Cells and Limits Long‐Term Survival of Kidney Graft

Advanced Science, EarlyView.
An effector subset of TRM, defined as CD49a+PD1hi CD8+ TRM, represents a BHLHE40‐orchestrated resident immune component that, rather than circulating cells, plays as a major contributor to allograft rejection. ABSTRACT Tissue‐resident memory T cells (TRM), which function against tumors, infections, and non‐self antigens in organ transplantation ...
Junbo Li, Bo Yang, Tianhui Pan, Xi Zhou, Zhibo Ma, Du Tang, Bowen Xie, Jing Liu, Zhishui Chen, Peixiang Lan   +9 more
wiley   +1 more source