Results 41 to 50 of about 136,550 (292)

An Implantable Scaffold Sequentially Releasing STING Agonist and B7‐H3 Antibody for Bone Metastasis Immunotherapy

Advanced Science, EarlyView.
We developed an implantable dual‐drug depot using GelMA for bone metastasis treatment, co‐delivering MSA‐2 and αB7‐H3‐loaded CaCO3 microparticles. Sustained release from GelMA scaffold enables MSA‐2 to activate STING signaling and enhance T‐cell infiltration and activation, while sequentially released αB7‐H3 blocks MSA‐2‐induced B7‐H3 upregulation ...
Qijun Lin, Hong Xiao, Shuai Fan, Kaimin Cai, Yanteng Xu, Xinwen Wang, Guanhong Chen, Chuandong Lang, Xinsheng Peng, Mingqiang Li, Yuhu Dai   +10 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Clinical variables of preoperative risk in thoracic surgery

São Paulo Medical Journal
CONTEXT: Pulmonary complications are the most common forms of postoperative morbidity in thoracic surgery, especially atelectasis and pneumonia. The first step in avoiding these complications during the postoperative period is to detect the patients that
Ivete Alonso Bredda Saad, Eduardo Mello De Capitani, Ivan Felizardo Contrera Toro, Lair Zambon   +3 more
doaj   +1 more source

Goal-directed haemodynamic therapy during elective total hip arthroplasty under regional anaesthesia.

, 2011
INTRODUCTION: Total hip replacement is one of the most commonly performed major orthopaedic operations. Goal-directed therapy (GDT) using haemodynamic monitoring has previously demonstrated outcome benefits in high-risk surgical patients under general ...
Michele Divella, Della Rocca, G, Nicola Langiano, Nicola Fasano, COSTA, Maria Gabriella, DELLA ROCCA, Giorgio, Fasano, N, Maria G Costa, Cecconi, M, Maurizio Cecconi, Divella, M, RHODES A, Rhodes, A, DIVELLA M, Costa, MG, Giorgio Rocca, FASANO N, CECCONI M, LANGIANO N, Langiano, N, Andrew Rhodes   +20 more
core   +1 more source

KRT14 Drives Basal Muscle‐Invasive Bladder Cancer Progression and Lung Metastasis by Directly Binding to and Stabilizing IGF2BP1

Advanced Science, EarlyView.
We identified a Krt14+ Igf2bp1+ bladder cancer population linked to EMT. Mechanistically, KRT14 stabilizes and transports IGF2BP1 to invasive protrusions, initiating a positive feedback loop that drives metastasis and poor outcomes. ABSTRACT Basal‐type muscle‐invasive bladder cancer (BMIBC) is characterized by aggressive metastasis and poor prognosis ...
Shirui Huang, Zhihan Zhou, Qipeng Xie, Zheng Wang, Lijiong He, Yutong Liu, Lijuan Huang, Liuxian Ye, Limeng Hu, Baokun Li, Yang Wang, Xiaohui Hua, Xuelei Liu, Yunping Zhao, Jingxia Li, Jinfei Chen, Guiying Wang, Xian Shen, Wei Chen, Chuanshu Huang   +19 more
wiley   +1 more source

Incidence of postoperative pulmonary complications.

, 2018
Incidence of postoperative pulmonary complications.
Weizhou Yang (5983298), Huiren Tao (345634), Chunguang Duan (5983301), Si Yin (4250302), Heng Du (278498), Yimin Yang (322868), Chaoshuai Feng (5983295)   +6 more
core   +1 more source

Factors Affecting Recollapse of the Augmented Vertebrae After Percutaneous Vertebral Augmentation: A Prospective Study

AGING MEDICINE, EarlyView.
To investigate the relevant factors of augmented vertebrae recollapse after percutaneous vertebral augmentation (PVA) for the treatment of osteoporotic vertebral compression fractures (OVCFs). Intervertebral cleft (IVC) and those with PVP intervention are at higher risk of recollapse.
Yawen Zhang, Junchuan Liu, Maoyu Zhao, Yudian Qiu, Quan Ji, Nan Min, Qiang Wang   +6 more
wiley   +1 more source

Predictive value of Chinese version of LAS VEGAS Risk Assessment Scale for occurrence status of postoperative pulmonary complications in critically ill patients

Huli yanjiu, 2023
ObjectiveTo investigate the predictive value of the Chinese version of the LAS VEGAS Risk Assessment Scale for postoperative pulmonary complications in critically ill patients.MethodsFrom January 2020 to December 2020，495 critically ill patients who ...
ZHANG Wenting, XU Jiaqing, GAO Yingying, LI Shengfang, DING Xiaorong   +4 more
doaj  

Impact of Abdominoperineal Resection on Postoperative Male Sexual Function After Minimally Invasive Rectal Cancer Surgery: A Subgroup Analysis From the LANDMARC Study

Annals of Gastroenterological Surgery, EarlyView.
Abdominoperineal resection (APR) after minimally invasive rectal cancer surgery was associated with significantly higher rates of erectile and early ejaculatory dysfunction compared with anal‐sparing surgery. Although ejaculatory function showed partial recovery over time, erectile dysfunction persisted up to 12 months postoperatively.
Taiki Kajiwara, Shinobu Ohnuma, Michiaki Unno, Masakatsu Numata, Tomohiro Yamaguchi, Koya Hida, Tomonori Akagi, Suguru Hasegawa, Akio Shiomi, Ryo Inada, Manabu Shiozawa, Keisuke Kazama, Masanori Hotchi, Masahiko Watanabe, Takeshi Naitoh   +14 more
wiley   +1 more source

Thirty-day postoperative cardiopulmonary complications in sarcoidosis: Insights from a retrospective matched cohort analysis

Anesthesiology and Perioperative Science
Purpose Sarcoidosis is a rare systemic granulomatous disorder characterized by lung involvement but frequently involves the heart, gastrointestinal and lymphatic organs.
Jonah C. Freund, Claudia Clarke Gosalvez, Alena Rady, Andrew Notarianni, Zyad J. Carr   +4 more
doaj   +1 more source