Results 71 to 80 of about 2,162 (176)

Thyroxine-binding globulin: investigation of microheterogeneity [PDF]

open access: yes, 1981
Preparations of T4-binding globulin (TBG) from human serum was performed using only two affinity chromatography steps. Purity of the protein was demonstrated by a single band in overloaded disc and sodium dodecyl sulfate electrophoresis, equimolar ...
Gärtner, Roland   +4 more
core   +1 more source

Impact of maternal thyroid dysfunction on fetal and maternal outcomes in pregnancy: a prospective cohort study

open access: yesClinical Diabetes and Endocrinology
Background Thyroid dysfunction in pregnancy can adversely impact maternal and fetal outcomes. However, the association between thyroid status and specific adverse outcomes needs clarity, especially in understudied regions.
Roshni Vamja   +6 more
doaj   +1 more source

Somatostatin modulation of initial fusion pores in Ca2+‐triggered exocytosis from mouse chromaffin cells

open access: yesThe Journal of Physiology, Volume 603, Issue 20, Page 6035-6050, October 15, 2025.
Abstract figure legend Somatostatin binds to a G‐protein‐coupled receptor to inhibit the release of catecholamine from chromaffin cells. This action has no impact on Ca2+ levels and is similar for Ca2+ entry through voltage‐gated Ca2 channels and for Ca2+ mobilization from the endoplasmic reticulum.
Jinbo Cheng, Meyer B. Jackson
wiley   +1 more source

Systematic Multi‐Trait Study of Genetic Correlation and Causality Relationships Between General Medical Conditions and Mental Disorders

open access: yesActa Psychiatrica Scandinavica, Volume 152, Issue 3, Page 236-249, September 2025.
ABSTRACT Introduction Increasing evidence has highlighted bidirectional associations between mental disorders and general medical conditions, with underlying causes ranging from lifestyle habits and side effects from medications to genetic contributions. Novel methods now provide a way to estimate the shared genetic underpinnings and the possibility of
Ron Nudel   +2 more
wiley   +1 more source

GADD45A is Essential for Granulosa Cells Differentiation and Ovarian Reserve in Human and Mice

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 17, September 2025.
ABSTRACT Diminished ovarian reserve (DOR) poses significant challenges in reproductive health, with emerging evidence implicating DNA damage repair pathways. While GADD45A is a critical regulator of DNA repair, cell cycle and apoptosis, its role in DOR pathogenesis remains unexplored. We employed transcriptome sequencing, qPCR and Western Blot analyses
Juncen Guo   +13 more
wiley   +1 more source

Endocrine risk factors of anxiety and depressive conditions in women in the postpartum period

open access: yesГинекология, 2013
76 women suffering from postpartum depression were included in the survey. In 36 cases the concomitant endocrine pathology (hypothyroidism and Hashimoto's thyroiditis, hyperthyroidism and hyperprolactinemia) was found.
N A Tatarova   +3 more
doaj  

Benign thyroid disease in pregnancy: A state of the art review

open access: yesJournal of Clinical & Translational Endocrinology, 2016
Thyroid dysfunction is the commonest endocrine disorder in pregnancy apart from diabetes. Thyroid hormones are essential for fetal brain development in the embryonic phase.
Efterpi Tingi   +4 more
doaj   +1 more source

Subclinical Hypothyroidism [PDF]

open access: yes, 2019
IMPORTANCE Subclinical hypothyroidism, defined as an elevated serum thyrotropin (often referred to as thyroid-stimulating hormone, or TSH) level with normal levels of free thyroxine (FT4) affects up to 10% of the adult population.
Biondi, B, Cappola, Ar, Cooper, Ds
core   +1 more source

Gestational age and fetal hypothyroidism Alter the porcine thyroid and local hepatic and renal renin‐angiotensin systems

open access: yesPhysiological Reports, Volume 13, Issue 17, September 2025.
Abstract This study was conducted to examine the ontogeny of and interactions between the thyroid system and local renin‐angiotensin systems (RAS) in the porcine fetus. N = 24 pregnant gilts were split into two groups, receiving either a daily dose of methimazole to induce fetal hypothyroidism, or a daily sham control. Within each group, treatment of n 
Alyssa A. Smith, J. Alex Pasternak
wiley   +1 more source

Autoimmunity in gestational diabetes mellitus in Sardinia: a preliminary case-control report [PDF]

open access: yes, 2008
Background: We previously reported a high prevalence (22.3%) of gestational diabetes mellitus (GDM) in a large group of Sardinian women, in contrast with the prevalence of Type 2 diabetes.
Cinzia Murgia   +40 more
core   +2 more sources

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