Results 81 to 90 of about 182,863 (189)

CCN1 Enhances Tumor Immunosuppression through Collagen‐Mediated Chemokine Secretion in Pancreatic Cancer

Advanced Science, EarlyView.
CCN1 modulates the tumor microenvironment in pancreatic cancer by promoting collagen‐dependent chemokine production, thereby facilitating immune evasion. Deletion of CCN1 not only suppresses tumor growth but also enhances immune cell infiltration and increases tumor sensitivity to both chemotherapy and immunotherapy.
Hongjie Fan, Huzi Zhao, Lili Gao, Yucheng Dong, Pei Zhang, Pengfei Yu, Yunfei Ji, Zhe‐Sheng Chen, Xinmiao Liang, Yang Chen   +9 more
wiley   +1 more source

Injectable and Sprayable Thermoresponsive Hydrogel with Fouling‐Resistance as an Effective Barrier to Prevent Postoperative Cardiac Adhesions

Advanced Science, EarlyView.
Postoperative cardiac adhesions lead to numerous difficulties in reoperation procedures. Here, a thermo‐responsive in situ formed hydrogel is shown to can reliably cover the wounds after a convenient spraying or injection and significantly reduce adhesion formation in primary and recurrent cardiac injury adhesion models.
Kun Shi, Tao Li, Xulin Hu, Wen Chen, Yan Yu, Zhongwu Bei, Liping Yuan, Qi Tong, Jiafeng Liu, Qiang Fan, Yongjun Qian, Zhiyong Qian   +11 more
wiley   +1 more source

Facile Synthesis of Two-Dimensional Natural Vermiculite Films for High-Performance Solid-State Electrolytes. [PDF]

Materials (Basel), 2023
Xing Y, Chen X, Huang Y, Zhen X, Wei L, Zhong X, Pan W.   +6 more
europepmc   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Noise-insensitive discriminative subspace fuzzy clustering. [PDF]

J Appl Stat, 2023
Zhi X, Yu T, Bi L, Li Y.
europepmc   +1 more source

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

A Neutral and Stable Macrocyclic Mn(II) Complex for MRI Tumor Visualization

ChemMedChem, Volume 17, Issue 24, December 16, 2022., 2022
Research on contrast agents for magnetic resonance imaging has recently guided efforts toward paramagnetic Mn(II) and Fe(III) complexes as alternatives to the well‐established Gd(III)‐based agents regularly used in clinical settings.The new neutral Mn(II) complex MnDO2AMGly reported herein shows good relaxometric performance, no toxicity, and in vivo ...
Loredana Leone, Annasofia Anemone, Antonella Carella, Elena Botto, Dario Livio Longo, Lorenzo Tei   +5 more
wiley   +1 more source

Sortilin‐Mediated Rapid, Precise and Sustained Degradation of Membrane Proteins via mRNA‐Encoded Lysosome‐Targeting Chimera

Advanced Science, EarlyView.
The study identified sortilin as a promising LTR, enabling targeted degradation of oncogenic proteins through an mRNA‐encoded MedTAC strategy. In a mouse model, MedTACPTK7 reduced PTK7 by up to 80%, extended survival, and showed excellent pharmacokinetics without toxicity, providing a scalable platform for targeted therapies.
Xin Chang, Xinyu Qiu, Xiaoning Tong, Shaoju Gan, Weicheng Yi, Sitao Xie, Xiangsheng Liu, Chao Zuo, Weihong Tan   +8 more
wiley   +1 more source

Investigation of the Physical Mechanism of Acoustic Attenuation in Viscous Isotropic Solids. [PDF]

Micromachines (Basel), 2022
Fa L, Li L, Gong H, Chen W, Jiang J, You G, Liang J, Zhang Y, Zhao M.   +8 more
europepmc   +1 more source

Turning Microstructure in Block Copolymer Membranes: A Facile Strategy to Improve CO2 Separation Performance

Advanced Science, EarlyView.
A simple and effective non‐solvent‐induced microstructure rearrangement (MSR) technique is proposed to enhance the gas separation performance of Pebax 2533 membranes. By immersing Pebax 2533 membranes in amino acid salt solutions to induce MSR, the CO2 permeability of the Pebax 2533‐GlyK 10 wt.% membrane reached 1180 Barrer.
Jing Wei, Min Deng, Zikang Qin, Weiyi Zhao, Yujie Li, Roman Selyanchyn, Hongyong Zhao, Jie Dong, Dengguo Yin, Yuanfa Zhuang, Liyuan Deng, Lin Yang, Lu Yao, Wenju Jiang, Junfeng Zheng, Bart Van der Bruggen, Zhongde Dai   +16 more
wiley   +1 more source