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Histone Posttranslational Modifications in Schizophrenia
2017Schizophrenia is a complex neuropsychiatric disorder with high heritability; however, family and twin studies have indicated that environmental factors also play important roles in the etiology of disease. Environmental triggers exert their influence on behavior via epigenetic mechanisms.
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Nonenzymatic posttranslational protein modifications in ageing
Experimental Gerontology, 2008One of the most fundamental molecular aspects of aging is accumulating oxidative damage caused by reactive oxygen species (ROS) as proposed by the free radical theory of aging. These unwanted chemical side products of normal metabolism lead to the formation of altered, less active and potentially toxic species of DNA, RNA, proteins, lipids, and small ...
Vukić, Soskić +2 more
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Posttranslational protein modifications
Critical Care Medicine, 2005Robert S B, Clark +2 more
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Proteome Analysis of Posttranslational Modifications
2003Publisher Summary The chapter focuses on current progress in the identification of protein modifications, with an emphasis on phosphorylation and glycosylation. One of the most important posttranslational protein modifications used to modulate protein activity and propagate signals within cellular pathways and networks is phosphorylation.
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Posttranslational Modifications of Tubulin
2012Recent studies have highlighted the potential importance of posttranslational modifications of tubulin in dictating response to antitumor drugs and disease progression. These modifications include glutamylation, glycylation, phosphorylation, acetylation, and tyrosination.
Suzan K. Chao +2 more
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Posttranslational Modification of Proteins
2015Proteins are subject to continuous reversible and irreversible modifications. These posttranslational modifications directly influence the stability and/or the function of proteins. Aging results in an increased half-life of proteins, which is associated with enhanced oxidative modifications of amino acid residues.
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