Results 71 to 80 of about 250,717 (298)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Europe's Journal of Psychology, 2019 Parkinson’s Disease (PD) is a progressive neurological condition characterized by motor and non-motor symptoms impacting life quality. The main aim of the current study was to investigate the effect of PD on objective (i.e., working memory and semantic ...
Maria Chiara Fastame +6 more
doaj +1 more source
Reliability and validity of three isometric back extensor strength assessments with different test postures [PDF]
, 2019 Sen Yang +8 more
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Rewire, Rebuild, Restore: Core Principles of Corrective Exercise for Clinicians [PDF]
Physical TreatmentsDespite growing interest in corrective exercise (CE), many professionals neglect the foundational principles. Also, the sources have not fully covered the fundamental principles of CE, underscoring the need for review and consolidation of CE principles ...
Hashem Piri
doaj
INFAD, 2017 Introduction: The Mézières is a postural therapy which consists in improving anatomical postures and mitigation until disappearances of muscular contractures while reducing back pain through the most important muscle recovery by positively contributing ...
Orges Lena +3 more
doaj +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Awareness of Ergonomic Principles and Implementation of Asana Practices Among Dental Clinic Professions in Iran [PDF]
Physical TreatmentsPurpose: Musculoskeletal disorders are among the most common complications associated with dental professions. This study aims to assess awareness of ergonomic principles and the application of asana-based exercises as a preventive rehabilitation ...
Karim Jafari Kafash +5 more
doaj